Injectable Hydrogel versus Plastically Compressed Collagen Scaffold for Central Nervous System Applications
المؤلفون المشاركون
Seifalian, Alexander Marcus
Tsintou, Magdalini
Dalamagkas, Kyriakos
المصدر
International Journal of Biomaterials
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Central Nervous System (CNS) repair has been a challenge, due to limited CNS tissue regenerative capacity.
The emerging tools that neural engineering has to offer have opened new pathways towards the discovery of novel therapeutic approaches for CNS disorders.
Collagen has been a preferable material for neural tissue engineering due to its similarity to the extracellular matrix, its biocompatibility, and antigenicity.
The aim was to compare properties of a plastically compressed collagen hydrogel with the ones of a promising collagen-genipin injectable hydrogel and a collagen-only hydrogel for clinical CNS therapy applications.
The focus was demonstrating the effects of genipin cross-linking versus plastic compression methodology on a collagen hydrogel and the impact of each method on clinical translatability.
The results showed that injectable collagen-genipin hydrogel is better clinical translation material.
Full collagen compression seemed to form extremely stiff hydrogels (up to about 2300 kPa) so, according to our findings, a compression level of up to 75% should be considered for CNS applications, being in line with CNS stiffness.
Taking that into consideration, partially compressed collagen 3D hydrogel systems may be a good tunable way to mimic the natural hierarchical model of the human body, potentially facilitating neural repair application.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tsintou, Magdalini& Dalamagkas, Kyriakos& Seifalian, Alexander Marcus. 2018. Injectable Hydrogel versus Plastically Compressed Collagen Scaffold for Central Nervous System Applications. International Journal of Biomaterials،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1169574
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tsintou, Magdalini…[et al.]. Injectable Hydrogel versus Plastically Compressed Collagen Scaffold for Central Nervous System Applications. International Journal of Biomaterials No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1169574
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tsintou, Magdalini& Dalamagkas, Kyriakos& Seifalian, Alexander Marcus. Injectable Hydrogel versus Plastically Compressed Collagen Scaffold for Central Nervous System Applications. International Journal of Biomaterials. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1169574
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1169574
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر