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Injectable Hydrogel versus Plastically Compressed Collagen Scaffold for Central Nervous System Applications
Joint Authors
Seifalian, Alexander Marcus
Tsintou, Magdalini
Dalamagkas, Kyriakos
Source
International Journal of Biomaterials
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Central Nervous System (CNS) repair has been a challenge, due to limited CNS tissue regenerative capacity.
The emerging tools that neural engineering has to offer have opened new pathways towards the discovery of novel therapeutic approaches for CNS disorders.
Collagen has been a preferable material for neural tissue engineering due to its similarity to the extracellular matrix, its biocompatibility, and antigenicity.
The aim was to compare properties of a plastically compressed collagen hydrogel with the ones of a promising collagen-genipin injectable hydrogel and a collagen-only hydrogel for clinical CNS therapy applications.
The focus was demonstrating the effects of genipin cross-linking versus plastic compression methodology on a collagen hydrogel and the impact of each method on clinical translatability.
The results showed that injectable collagen-genipin hydrogel is better clinical translation material.
Full collagen compression seemed to form extremely stiff hydrogels (up to about 2300 kPa) so, according to our findings, a compression level of up to 75% should be considered for CNS applications, being in line with CNS stiffness.
Taking that into consideration, partially compressed collagen 3D hydrogel systems may be a good tunable way to mimic the natural hierarchical model of the human body, potentially facilitating neural repair application.
American Psychological Association (APA)
Tsintou, Magdalini& Dalamagkas, Kyriakos& Seifalian, Alexander Marcus. 2018. Injectable Hydrogel versus Plastically Compressed Collagen Scaffold for Central Nervous System Applications. International Journal of Biomaterials،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1169574
Modern Language Association (MLA)
Tsintou, Magdalini…[et al.]. Injectable Hydrogel versus Plastically Compressed Collagen Scaffold for Central Nervous System Applications. International Journal of Biomaterials No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1169574
American Medical Association (AMA)
Tsintou, Magdalini& Dalamagkas, Kyriakos& Seifalian, Alexander Marcus. Injectable Hydrogel versus Plastically Compressed Collagen Scaffold for Central Nervous System Applications. International Journal of Biomaterials. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1169574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169574