Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?
المؤلفون المشاركون
Mongioi’, Laura
Cannarella, Rossella
Dall’Oglio, Federica
Micali, Giuseppe
Condorelli, Rosita A.
La Vignera, Sandro
Calogero, Aldo E.
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Increased dehydroepiandrosterone sulfate (DHEAS) levels have been reported in men with early-onset (<35 years) androgenetic alopecia (AGA).
It has been suggested that a male polycystic ovarian syndrome- (PCOS-) equivalent, defined as an endocrine syndrome with a metabolic background and a PCOS-like hormonal pattern, predisposing to type II diabetes mellitus (DM II), cardiovascular and prostate diseases later in life, may occur in at least a part of these men.
The gonadal function, including sperm parameters and total testosterone (TT) levels, has been investigated in a low number of these men.
Objective.
The aim of the study was to assess gonadal and adrenal function in a subset of men with early-onset AGA and controls.
Methods.
43 men with early-onset AGA and 36 controls were screened for DHEAS, TT, glycaemia, insulin, gonadotropins, 17α-hydroxyprogesterone (17αOH-P), testicular volume (TV), fat mass percentage, and sperm conventional parameters.
Among men with AGA, we identified Group 1 (n = 21), as those with at least one of the following parameters: body mass index (BMI) >25 kg/m2, insulin resistance (IR), and/or SHBG <25 nmol/l.
Results.
Patients with early-onset AGA had higher mean (±SD) BMI (25.5 ± 3.8 vs.
23.7 ± 3.0 kg/m2; P<0.05) and 17αOH-progesterone (2.1 ± 0.9 vs.
1.5 ± 0.6 ng/ml; P<0.05) compared to controls.
Group 1 had higher BMI (27.9 ± 3.8 vs.
23.7 ± 3.8 ml; P<0.05), fat-mass percentage (17.5 ± 4.1 vs.
13.2 ± 5.3; P<0.05), HOMA index (2.5 ± 1.8 vs.
1.5 ± 0.7; P<0.05), DHEAS (323.3 ± 112.6 vs.
257.8 ± 107.1 μg/dl; P<0.05), seminal fluid volume (4.2 ± 2.8 vs.
2.8 ± 1.3 ml; P<0.05), lower TT (5.16 ± 1.70 vs.
6.47 ± 4.30 ng/ml; P=0.016), and left TV (12.3 ± 2.8 vs.
15.0 ± 4.3 ml; P<0.05) compared to controls.
Conclusion.
Men with early-onset AGA and at least one among BMI >25 kg/m2, IR, and SHBG <25 nmol/l have increased DHEAS levels and a worse gonadal steroidogenesis.
They might have a greater risk to develop gonadal dysfunction later in life.
These criteria may be used to define male PCOS-equivalent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cannarella, Rossella& Condorelli, Rosita A.& Dall’Oglio, Federica& La Vignera, Sandro& Mongioi’, Laura& Micali, Giuseppe…[et al.]. 2020. Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170132
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cannarella, Rossella…[et al.]. Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?. International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170132
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cannarella, Rossella& Condorelli, Rosita A.& Dall’Oglio, Federica& La Vignera, Sandro& Mongioi’, Laura& Micali, Giuseppe…[et al.]. Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170132
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170132
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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