Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?
Joint Authors
Mongioi’, Laura
Cannarella, Rossella
Dall’Oglio, Federica
Micali, Giuseppe
Condorelli, Rosita A.
La Vignera, Sandro
Calogero, Aldo E.
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Increased dehydroepiandrosterone sulfate (DHEAS) levels have been reported in men with early-onset (<35 years) androgenetic alopecia (AGA).
It has been suggested that a male polycystic ovarian syndrome- (PCOS-) equivalent, defined as an endocrine syndrome with a metabolic background and a PCOS-like hormonal pattern, predisposing to type II diabetes mellitus (DM II), cardiovascular and prostate diseases later in life, may occur in at least a part of these men.
The gonadal function, including sperm parameters and total testosterone (TT) levels, has been investigated in a low number of these men.
Objective.
The aim of the study was to assess gonadal and adrenal function in a subset of men with early-onset AGA and controls.
Methods.
43 men with early-onset AGA and 36 controls were screened for DHEAS, TT, glycaemia, insulin, gonadotropins, 17α-hydroxyprogesterone (17αOH-P), testicular volume (TV), fat mass percentage, and sperm conventional parameters.
Among men with AGA, we identified Group 1 (n = 21), as those with at least one of the following parameters: body mass index (BMI) >25 kg/m2, insulin resistance (IR), and/or SHBG <25 nmol/l.
Results.
Patients with early-onset AGA had higher mean (±SD) BMI (25.5 ± 3.8 vs.
23.7 ± 3.0 kg/m2; P<0.05) and 17αOH-progesterone (2.1 ± 0.9 vs.
1.5 ± 0.6 ng/ml; P<0.05) compared to controls.
Group 1 had higher BMI (27.9 ± 3.8 vs.
23.7 ± 3.8 ml; P<0.05), fat-mass percentage (17.5 ± 4.1 vs.
13.2 ± 5.3; P<0.05), HOMA index (2.5 ± 1.8 vs.
1.5 ± 0.7; P<0.05), DHEAS (323.3 ± 112.6 vs.
257.8 ± 107.1 μg/dl; P<0.05), seminal fluid volume (4.2 ± 2.8 vs.
2.8 ± 1.3 ml; P<0.05), lower TT (5.16 ± 1.70 vs.
6.47 ± 4.30 ng/ml; P=0.016), and left TV (12.3 ± 2.8 vs.
15.0 ± 4.3 ml; P<0.05) compared to controls.
Conclusion.
Men with early-onset AGA and at least one among BMI >25 kg/m2, IR, and SHBG <25 nmol/l have increased DHEAS levels and a worse gonadal steroidogenesis.
They might have a greater risk to develop gonadal dysfunction later in life.
These criteria may be used to define male PCOS-equivalent.
American Psychological Association (APA)
Cannarella, Rossella& Condorelli, Rosita A.& Dall’Oglio, Federica& La Vignera, Sandro& Mongioi’, Laura& Micali, Giuseppe…[et al.]. 2020. Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170132
Modern Language Association (MLA)
Cannarella, Rossella…[et al.]. Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?. International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170132
American Medical Association (AMA)
Cannarella, Rossella& Condorelli, Rosita A.& Dall’Oglio, Federica& La Vignera, Sandro& Mongioi’, Laura& Micali, Giuseppe…[et al.]. Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170132