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The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism
المؤلفون المشاركون
Liu, Simo
Sun, Rongxin
An, Yaxin
Cao, Bin
Ke, Jing
Zhao, Dong
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aims.
Hashimoto’s thyroiditis (HT), a type of autoimmune disease, occurs due to genetic predisposition and environmental factors.
It is well known that thyroid function may affect the gut microbiota.
However, the composition of gut microbiota in HT patients with different thyroid function status has been less highlighted.
Therefore, we focused on the alterations in the composition of gut microbiota in HT patients with euthyroidism and hypothyroidism.
Methods.
We performed a cross-sectional study, including 45 HT patients with euthyroidism, 18 HT patients with hypothyroidism, and 34 healthy controls.
Fecal samples were collected, and microbiota was examined by using 16S RNA ribosomal RNA gene sequencing.
Then, we analyzed the possible pathways in relation to the enriched bacteria by linear discriminant analysis (LDA) effect size (LEfSe).
Results.
Compared with the controls, bacterial richness and diversity were significantly lower in patients with HT, especially in hypothyroidism.
Moreover, Lachnospiraceae_incertae_sedis, Lactonifactor, Alistipes, and Subdoligranulum were more enriched in HT patients with euthyroidism, while Phascolarctobacterium was more abundant in those with hypothyroidism.
Further analysis suggested that Phascolarctobacterium was negatively related to several pathways, including environmental information processing and metabolism.
Conclusion.
In summary, our study demonstrated the altered composition of gut microbiota in HT patients with different thyroid function status.
Moreover, Phascolarctobacterium may be involved in the development of HT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Simo& An, Yaxin& Cao, Bin& Sun, Rongxin& Ke, Jing& Zhao, Dong. 2020. The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1170334
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Simo…[et al.]. The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism. International Journal of Endocrinology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1170334
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Simo& An, Yaxin& Cao, Bin& Sun, Rongxin& Ke, Jing& Zhao, Dong. The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1170334
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170334
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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