The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism
Joint Authors
Liu, Simo
Sun, Rongxin
An, Yaxin
Cao, Bin
Ke, Jing
Zhao, Dong
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
Hashimoto’s thyroiditis (HT), a type of autoimmune disease, occurs due to genetic predisposition and environmental factors.
It is well known that thyroid function may affect the gut microbiota.
However, the composition of gut microbiota in HT patients with different thyroid function status has been less highlighted.
Therefore, we focused on the alterations in the composition of gut microbiota in HT patients with euthyroidism and hypothyroidism.
Methods.
We performed a cross-sectional study, including 45 HT patients with euthyroidism, 18 HT patients with hypothyroidism, and 34 healthy controls.
Fecal samples were collected, and microbiota was examined by using 16S RNA ribosomal RNA gene sequencing.
Then, we analyzed the possible pathways in relation to the enriched bacteria by linear discriminant analysis (LDA) effect size (LEfSe).
Results.
Compared with the controls, bacterial richness and diversity were significantly lower in patients with HT, especially in hypothyroidism.
Moreover, Lachnospiraceae_incertae_sedis, Lactonifactor, Alistipes, and Subdoligranulum were more enriched in HT patients with euthyroidism, while Phascolarctobacterium was more abundant in those with hypothyroidism.
Further analysis suggested that Phascolarctobacterium was negatively related to several pathways, including environmental information processing and metabolism.
Conclusion.
In summary, our study demonstrated the altered composition of gut microbiota in HT patients with different thyroid function status.
Moreover, Phascolarctobacterium may be involved in the development of HT.
American Psychological Association (APA)
Liu, Simo& An, Yaxin& Cao, Bin& Sun, Rongxin& Ke, Jing& Zhao, Dong. 2020. The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1170334
Modern Language Association (MLA)
Liu, Simo…[et al.]. The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism. International Journal of Endocrinology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1170334
American Medical Association (AMA)
Liu, Simo& An, Yaxin& Cao, Bin& Sun, Rongxin& Ke, Jing& Zhao, Dong. The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1170334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170334