SNP Analysis of Caries and Initial Caries in Finnish Adolescents
المؤلفون المشاركون
Heikkinen, Anna-Maria
Tervahartiala, Taina
Raivisto, Teija
Kovanen, Leena
Ruokonen, Hellevi
Kettunen, Kaisa
Haukka, Jari
Sorsa, Timo
المصدر
International Journal of Dentistry
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Dental caries is the most common infection in the world and is influenced by genetic and environmental factors.
Environmental factors are largely known, but the role of genetic factors is quite unknown.
The aim was to investigate the genetic background of caries in Finnish adolescents.
Materials and Methods.
This study was carried out at the Kotka Health Center in Eastern Finland.
94 participants aged 15–17 years gave approval for the saliva and DNA analyses.
However, one was excluded in DNA analysis; thus, the overall number of participants in analysis was 93.
Caries status was recorded clinically and from bite-wing X-rays to all 94 participants.
Genomic DNA was extracted by genomic QIAamp® DNA Blood Mini Kit and genotyped for polymorphisms.
The results were analyzed using additive and logistic regression models.
Results.
No significant associations between caries and the genes studied were found.
However, SNPs in DDX39B and MPO showed association tendencies but were not statistically significant after false discovery rate (FDR) analysis.
SNPs in VDR, LTA, and MMP3 were not statistically significant with initial caries lesions after FDR analysis.
Conclusion.
The present study could not demonstrate statistically significant associations between caries and the genes studied.
Further studies with larger populations are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Raivisto, Teija& Heikkinen, Anna-Maria& Kovanen, Leena& Ruokonen, Hellevi& Kettunen, Kaisa& Tervahartiala, Taina…[et al.]. 2018. SNP Analysis of Caries and Initial Caries in Finnish Adolescents. International Journal of Dentistry،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1170391
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Raivisto, Teija…[et al.]. SNP Analysis of Caries and Initial Caries in Finnish Adolescents. International Journal of Dentistry No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1170391
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Raivisto, Teija& Heikkinen, Anna-Maria& Kovanen, Leena& Ruokonen, Hellevi& Kettunen, Kaisa& Tervahartiala, Taina…[et al.]. SNP Analysis of Caries and Initial Caries in Finnish Adolescents. International Journal of Dentistry. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1170391
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170391
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر