SNP Analysis of Caries and Initial Caries in Finnish Adolescents
Joint Authors
Heikkinen, Anna-Maria
Tervahartiala, Taina
Raivisto, Teija
Kovanen, Leena
Ruokonen, Hellevi
Kettunen, Kaisa
Haukka, Jari
Sorsa, Timo
Source
International Journal of Dentistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Dental caries is the most common infection in the world and is influenced by genetic and environmental factors.
Environmental factors are largely known, but the role of genetic factors is quite unknown.
The aim was to investigate the genetic background of caries in Finnish adolescents.
Materials and Methods.
This study was carried out at the Kotka Health Center in Eastern Finland.
94 participants aged 15–17 years gave approval for the saliva and DNA analyses.
However, one was excluded in DNA analysis; thus, the overall number of participants in analysis was 93.
Caries status was recorded clinically and from bite-wing X-rays to all 94 participants.
Genomic DNA was extracted by genomic QIAamp® DNA Blood Mini Kit and genotyped for polymorphisms.
The results were analyzed using additive and logistic regression models.
Results.
No significant associations between caries and the genes studied were found.
However, SNPs in DDX39B and MPO showed association tendencies but were not statistically significant after false discovery rate (FDR) analysis.
SNPs in VDR, LTA, and MMP3 were not statistically significant with initial caries lesions after FDR analysis.
Conclusion.
The present study could not demonstrate statistically significant associations between caries and the genes studied.
Further studies with larger populations are needed.
American Psychological Association (APA)
Raivisto, Teija& Heikkinen, Anna-Maria& Kovanen, Leena& Ruokonen, Hellevi& Kettunen, Kaisa& Tervahartiala, Taina…[et al.]. 2018. SNP Analysis of Caries and Initial Caries in Finnish Adolescents. International Journal of Dentistry،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1170391
Modern Language Association (MLA)
Raivisto, Teija…[et al.]. SNP Analysis of Caries and Initial Caries in Finnish Adolescents. International Journal of Dentistry No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1170391
American Medical Association (AMA)
Raivisto, Teija& Heikkinen, Anna-Maria& Kovanen, Leena& Ruokonen, Hellevi& Kettunen, Kaisa& Tervahartiala, Taina…[et al.]. SNP Analysis of Caries and Initial Caries in Finnish Adolescents. International Journal of Dentistry. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1170391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170391