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Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity
المؤلفون المشاركون
Ricotti, Roberta
De Feudis, Marilisa
Peri, Caterina
Corazzari, Marco
Genoni, Giulia
Giordano, Mara
Mancioppi, Valentina
Agosti, Emanuela
Bellone, Simonetta
Prodam, Flavia
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
Haptoglobin (Hp) is a protein involved in the acute-phase reaction of inflammation.
Humans have three major phenotypes (Hp1-1, Hp1-2, and Hp2-2).
Several studies have shown altered Hp regulation in adults with obesity and metabolic alterations.
The Hp2-2 phenotype is associated with a high cardiovascular risk.
Our aim was to investigate if Hp levels and the Hp2-2 phenotype are associated with glucose metabolism in pediatric obesity.
Methods.
We retrospectively studied 192 participants (92 males and 100 females), aged 4–18 years.
Clinical and biochemical data were collected.
The Hp phenotype (Hp1-1, Hp1-2, and Hp2-2) was identified through Western immunoblot.
Results.
Subjects carrying Hp1-1, Hp1-2, and Hp2-2 phenotypes were 13.6, 50.8, and 35.6%, respectively.
Hp serum, fasting glucose, and insulin levels, as well as HOMA-IR, were similar among groups.
Postload glucose and insulin levels (as insulin AUC) were progressively higher from the Hp1-1 to Hp2-2 phenotype.
Conclusion.
To our knowledge, this is the first study on Hp phenotypes conducted in a pediatric population with obesity.
We showed that the presence of Hp2 allele is associated with a worse response of glucose load in terms of both glucose and insulin levels.
Thus, the Hp2-2 phenotype could predispose in pediatrics, at the same degree of obesity, to a worse glycemic and insulinemic compensation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ricotti, Roberta& De Feudis, Marilisa& Peri, Caterina& Corazzari, Marco& Genoni, Giulia& Giordano, Mara…[et al.]. 2020. Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170395
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ricotti, Roberta…[et al.]. Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity. International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170395
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ricotti, Roberta& De Feudis, Marilisa& Peri, Caterina& Corazzari, Marco& Genoni, Giulia& Giordano, Mara…[et al.]. Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170395
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170395
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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