Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity
Joint Authors
Ricotti, Roberta
De Feudis, Marilisa
Peri, Caterina
Corazzari, Marco
Genoni, Giulia
Giordano, Mara
Mancioppi, Valentina
Agosti, Emanuela
Bellone, Simonetta
Prodam, Flavia
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Haptoglobin (Hp) is a protein involved in the acute-phase reaction of inflammation.
Humans have three major phenotypes (Hp1-1, Hp1-2, and Hp2-2).
Several studies have shown altered Hp regulation in adults with obesity and metabolic alterations.
The Hp2-2 phenotype is associated with a high cardiovascular risk.
Our aim was to investigate if Hp levels and the Hp2-2 phenotype are associated with glucose metabolism in pediatric obesity.
Methods.
We retrospectively studied 192 participants (92 males and 100 females), aged 4–18 years.
Clinical and biochemical data were collected.
The Hp phenotype (Hp1-1, Hp1-2, and Hp2-2) was identified through Western immunoblot.
Results.
Subjects carrying Hp1-1, Hp1-2, and Hp2-2 phenotypes were 13.6, 50.8, and 35.6%, respectively.
Hp serum, fasting glucose, and insulin levels, as well as HOMA-IR, were similar among groups.
Postload glucose and insulin levels (as insulin AUC) were progressively higher from the Hp1-1 to Hp2-2 phenotype.
Conclusion.
To our knowledge, this is the first study on Hp phenotypes conducted in a pediatric population with obesity.
We showed that the presence of Hp2 allele is associated with a worse response of glucose load in terms of both glucose and insulin levels.
Thus, the Hp2-2 phenotype could predispose in pediatrics, at the same degree of obesity, to a worse glycemic and insulinemic compensation.
American Psychological Association (APA)
Ricotti, Roberta& De Feudis, Marilisa& Peri, Caterina& Corazzari, Marco& Genoni, Giulia& Giordano, Mara…[et al.]. 2020. Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170395
Modern Language Association (MLA)
Ricotti, Roberta…[et al.]. Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity. International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170395
American Medical Association (AMA)
Ricotti, Roberta& De Feudis, Marilisa& Peri, Caterina& Corazzari, Marco& Genoni, Giulia& Giordano, Mara…[et al.]. Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170395
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170395