Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue
المؤلفون المشاركون
Sato, Yasufumi
Takeda, Eichi
Suzuki, Yasuhiro
Katagiri, Hideki
Yamada, Tetsuya
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-06
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Vasohibin-1 (Vash1), originally isolated as an endothelium-derived angiogenesis inhibitor, has a characteristic of promoting stress tolerance in endothelial cells (ECs).
We therefore speculated that the lack of the vash1 gene would result in a short lifespan.
However, to our surprise, vash1−/− mice lived significantly longer with a milder senescence phenotype than wild-type (WT) mice.
We sought the cause of this healthy longevity and found that vash1−/− mice exhibited mild insulin resistance along with reduced expression of the insulin receptor (insr), insulin receptor substrate 1 (irs-1), and insulin receptor substrate 2 (irs-2) in their white adipose tissue (WAT) but not in their liver or skeletal muscle.
The expression of vash1 dominated in the WAT among those 3 organs.
Importantly, vash1−/− mice did not develop diabetes even when fed a high-fat diet.
These results indicate that the expression of vash1 was required for the normal insulin sensitivity of the WAT and that the target molecules for this activity were insr, irs1, and irs2.
The lack of vash1 caused mild insulin resistance without the outbreak of overt diabetes and might contribute to healthy longevity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takeda, Eichi& Suzuki, Yasuhiro& Yamada, Tetsuya& Katagiri, Hideki& Sato, Yasufumi. 2017. Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue. Journal of Aging Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1170434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takeda, Eichi…[et al.]. Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue. Journal of Aging Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1170434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takeda, Eichi& Suzuki, Yasuhiro& Yamada, Tetsuya& Katagiri, Hideki& Sato, Yasufumi. Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue. Journal of Aging Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1170434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر