Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism
المؤلفون المشاركون
Guo, Shan
Yuan, Tao
Jiang, Haoyu
Liu, Ying
Tal, Reshef
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-23
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Objective.
Evidence suggests that vitamin D deficiency correlated with metabolic disorders in women with polycystic ovary syndrome (PCOS).
We conducted this systematic review and meta-analysis to evaluate the impact of vitamin D supplementation alone on glucose, lipid, and androgen parameters and inflammation biomarkers in women with PCOS.
Methods.
Literature research was conducted in Pubmed, Embase, Web of Science, Clinical Trials, and Cochrane Library to identify relevant randomized controlled trials (RCTs) up to March 2020.
The effect of vitamin D supplementation alone on women with PCOS was compared with administration of placebo.
The systematic review and meta-analysis protocol was registered in the International Prospective Register of Systematic Reviews (Prospero) as number CRD42020157444.
Results.
Thirteen randomized controlled trials with 824 patients in total were included.
Serum FPG, fasting insulin, HOMA-IR, and VLDL-C were significantly decreased in the vitamin D group versus placebo.
Vitamin D supplementation group also showed a significantly elevated level of QUICKI.
No significant impact was seen on serum triglyceride, total-C, LDL-C, HDL-C, total testosterone, DHEAS, SHBG, or hs-CRP.
Subgroup analysis demonstrated that oral vitamin D intake had significantly decreased serum triglyceride and total-C level in women with PCOS who have vitamin D deficiency (serum vitamin D < 20 ng/ml).
Conclusion.
The findings of the present meta-analysis indicate that vitamin D supplementation exerted favorable effects among women with PCOS on glucose metabolism and lipid metabolism, especially in vitamin D deficient women, but had no significant effect on the androgenic profile or inflammation status.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Shan& Tal, Reshef& Jiang, Haoyu& Yuan, Tao& Liu, Ying. 2020. Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1170487
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Shan…[et al.]. Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism. International Journal of Endocrinology No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1170487
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Shan& Tal, Reshef& Jiang, Haoyu& Yuan, Tao& Liu, Ying. Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1170487
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170487
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر