Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism

Joint Authors

Guo, Shan
Yuan, Tao
Jiang, Haoyu
Liu, Ying
Tal, Reshef

Source

International Journal of Endocrinology

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-18, 18 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-23

Country of Publication

Egypt

No. of Pages

18

Main Subjects

Biology

Abstract EN

Objective.

Evidence suggests that vitamin D deficiency correlated with metabolic disorders in women with polycystic ovary syndrome (PCOS).

We conducted this systematic review and meta-analysis to evaluate the impact of vitamin D supplementation alone on glucose, lipid, and androgen parameters and inflammation biomarkers in women with PCOS.

Methods.

Literature research was conducted in Pubmed, Embase, Web of Science, Clinical Trials, and Cochrane Library to identify relevant randomized controlled trials (RCTs) up to March 2020.

The effect of vitamin D supplementation alone on women with PCOS was compared with administration of placebo.

The systematic review and meta-analysis protocol was registered in the International Prospective Register of Systematic Reviews (Prospero) as number CRD42020157444.

Results.

Thirteen randomized controlled trials with 824 patients in total were included.

Serum FPG, fasting insulin, HOMA-IR, and VLDL-C were significantly decreased in the vitamin D group versus placebo.

Vitamin D supplementation group also showed a significantly elevated level of QUICKI.

No significant impact was seen on serum triglyceride, total-C, LDL-C, HDL-C, total testosterone, DHEAS, SHBG, or hs-CRP.

Subgroup analysis demonstrated that oral vitamin D intake had significantly decreased serum triglyceride and total-C level in women with PCOS who have vitamin D deficiency (serum vitamin D < 20 ng/ml).

Conclusion.

The findings of the present meta-analysis indicate that vitamin D supplementation exerted favorable effects among women with PCOS on glucose metabolism and lipid metabolism, especially in vitamin D deficient women, but had no significant effect on the androgenic profile or inflammation status.

American Psychological Association (APA)

Guo, Shan& Tal, Reshef& Jiang, Haoyu& Yuan, Tao& Liu, Ying. 2020. Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1170487

Modern Language Association (MLA)

Guo, Shan…[et al.]. Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism. International Journal of Endocrinology No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1170487

American Medical Association (AMA)

Guo, Shan& Tal, Reshef& Jiang, Haoyu& Yuan, Tao& Liu, Ying. Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1170487

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1170487