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Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System
المؤلفون المشاركون
Plunk, Elizabeth C.
Richards, Sean M.
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The epigenome of an individual can be altered by endogenous hormones, environment, age, diet, and exposure to endocrine disrupting chemicals (EDCs), and the effects of these modifications can be seen across generations.
Epigenetic modifications to the genome can alter the phenotype of the individual without altering the DNA sequence itself.
Epigenetic modifications include DNA methylation, histone modification, and aberrant microRNA (miRNA) expression; they begin during germ cell development and embryogenesis and continue until death.
Hormone modulation occurs during the ageing process due to epigenetic modifications.
Maternal overnutrition or undernutrition can affect the epigenome of the fetus, and the effects can be seen throughout life.
Furthermore, maternal care during the childhood of the offspring can lead to different phenotypes seen in adulthood.
Diseases controlled by the endocrine system, such as obesity and diabetes, as well as infertility in females can be associated with epigenetic changes.
Not only can these phenotypes be seen in F1, but also some chemical effects can be passed through the germline and have effects transgenerationally, and the phenotypes are seen in F3.
The following literature review expands upon these topics and discusses the state of the science related to epigenetic effects of age, diet, and EDCs on the endocrine system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Plunk, Elizabeth C.& Richards, Sean M.. 2020. Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1170623
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Plunk, Elizabeth C.& Richards, Sean M.. Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System. International Journal of Endocrinology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1170623
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Plunk, Elizabeth C.& Richards, Sean M.. Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1170623
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170623
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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