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Lactobacillus rhamnosus Reduces Blood Glucose Level through Downregulation of Gluconeogenesis Gene Expression in Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Farida, Eko
Nuraida, Lilis
Giriwono, Puspo E.
Jenie, Betty S. L.
المصدر
International Journal of Food Science
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-13
دولة النشر
مصر
عدد الصفحات
12
الملخص EN
Some lactic acid bacteria (LAB) are observed to be potential probiotics with functional properties such as lowering fasting blood glucose (FBG), as a promising hyperglycemia management.
This study investigated the ability and mechanism of Lactobacillus rhamnosus BSL and Lactobacillus rhamnosus R23 on lowering FBG in diabetic rats induced by streptozotocin (STZ).
The rats were orally administered with L.
rhamnosus BSL and L.
rhamnosus R23 by giving 1 mL cell suspension (109 CFU/mL) daily for 30 days.
The body weight (BW) was recorded once in three days, and FBG was recorded once in six days.
An oral glucose tolerance test (OGTT) was measured 1 week after injection with STZ and before sacrifice.
Fecal samples were collected on days 0, 15, and 30 for LAB population and identification, performed by PCR detecting 16S rRNA.
Oral administration of L.
rhamnosus BSL and L.
rhamnosus R23 decreased FBG and improved glucose tolerance via downregulation of glucose-6-phosphatase (G6pc) expression by 0.57- and 0.60-fold change, respectively (P<0.05).
The lipid profiles, BUN, creatinine, SGOT, and SGPT were significantly (P<0.05) different between normal and diabetic rats, but they were not significantly (P>0.05) different among diabetic rats.
Both strains were effective in increasing fecal LAB population.
Molecular identification of the isolated LAB from fecal sample indicated that they were able to survive and pass through the digestive tract.
These results suggested that both strains have the ability to manage blood glucose level and become a promising agent to manage hyperglycemia and diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Farida, Eko& Nuraida, Lilis& Giriwono, Puspo E.& Jenie, Betty S. L.. 2020. Lactobacillus rhamnosus Reduces Blood Glucose Level through Downregulation of Gluconeogenesis Gene Expression in Streptozotocin-Induced Diabetic Rats. International Journal of Food Science،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1171019
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Farida, Eko…[et al.]. Lactobacillus rhamnosus Reduces Blood Glucose Level through Downregulation of Gluconeogenesis Gene Expression in Streptozotocin-Induced Diabetic Rats. International Journal of Food Science No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1171019
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Farida, Eko& Nuraida, Lilis& Giriwono, Puspo E.& Jenie, Betty S. L.. Lactobacillus rhamnosus Reduces Blood Glucose Level through Downregulation of Gluconeogenesis Gene Expression in Streptozotocin-Induced Diabetic Rats. International Journal of Food Science. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1171019
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171019
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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