Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy
المؤلفون المشاركون
Miśkiewicz, Piotr
Jankowska, Anna
Brodzińska, Kinga
Milczarek-Banach, Justyna
Ambroziak, Urszula
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
Intravenous methylprednisolone (IVMP) pulse therapy is the first-line treatment in active moderate-to-severe Graves’ orbitopathy (GO) and dysthyroid optic neuropathy (DON).
One of the adverse effects of this therapy is liver dysfunction that can be mild (ALT < 100 U/L), moderate (ALT: 100–300 U/L), and severe defined as acute liver injury (ALI) (ALT > 300 U/L).
ALI can be irreversible and fatal.
The aim of the study was to evaluate the influence of two different schemes of therapy with IVMP in moderate-to-severe GO and DON on biochemical liver parameters.
Materials and Methods.
49 patients with moderate-to-severe GO were treated with IVMP in every week schedule (cumulative dose 4.5 g), and 19 patients with DON received 3.0 g IVMP (1.0 g/day for 3 consecutive days).
AST, ALT, and total bilirubin were measured before treatment and after IVMP in the following selected pulses: after 0.5 g (A1), 3.0 g (A2), and 4.5 g (A3) in the group with moderate-to-severe GO and after 3.0 g IVMP in the group with DON (B1).
Results.
We observed a statistically higher level of AST and ALT after therapy with 3.0 g of IVMP (B1) than after 0.5 g (A1), 3.0 g (A2), and 4.5 g of IVMP (A3).
Mild elevation of ALT was found in 4% and 11% of patients with moderate-to-severe GO and DON, respectively.
Moderate elevation of ALT was found in 0% and 21% of patients with moderate-to-severe GO and DON, respectively.
There were no cases of ALI.
Conclusion.
Therapy of GO with higher doses (1.0 g) of IVMP in consecutive days is associated with higher risk of liver damage than treatment with moderate doses (≤0.5 g) in every week schedule.
This trial is registered with NCT03667157.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miśkiewicz, Piotr& Jankowska, Anna& Brodzińska, Kinga& Milczarek-Banach, Justyna& Ambroziak, Urszula. 2018. Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171118
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miśkiewicz, Piotr…[et al.]. Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy. International Journal of Endocrinology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1171118
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miśkiewicz, Piotr& Jankowska, Anna& Brodzińska, Kinga& Milczarek-Banach, Justyna& Ambroziak, Urszula. Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171118
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171118
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر