Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy
Joint Authors
Miśkiewicz, Piotr
Jankowska, Anna
Brodzińska, Kinga
Milczarek-Banach, Justyna
Ambroziak, Urszula
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Intravenous methylprednisolone (IVMP) pulse therapy is the first-line treatment in active moderate-to-severe Graves’ orbitopathy (GO) and dysthyroid optic neuropathy (DON).
One of the adverse effects of this therapy is liver dysfunction that can be mild (ALT < 100 U/L), moderate (ALT: 100–300 U/L), and severe defined as acute liver injury (ALI) (ALT > 300 U/L).
ALI can be irreversible and fatal.
The aim of the study was to evaluate the influence of two different schemes of therapy with IVMP in moderate-to-severe GO and DON on biochemical liver parameters.
Materials and Methods.
49 patients with moderate-to-severe GO were treated with IVMP in every week schedule (cumulative dose 4.5 g), and 19 patients with DON received 3.0 g IVMP (1.0 g/day for 3 consecutive days).
AST, ALT, and total bilirubin were measured before treatment and after IVMP in the following selected pulses: after 0.5 g (A1), 3.0 g (A2), and 4.5 g (A3) in the group with moderate-to-severe GO and after 3.0 g IVMP in the group with DON (B1).
Results.
We observed a statistically higher level of AST and ALT after therapy with 3.0 g of IVMP (B1) than after 0.5 g (A1), 3.0 g (A2), and 4.5 g of IVMP (A3).
Mild elevation of ALT was found in 4% and 11% of patients with moderate-to-severe GO and DON, respectively.
Moderate elevation of ALT was found in 0% and 21% of patients with moderate-to-severe GO and DON, respectively.
There were no cases of ALI.
Conclusion.
Therapy of GO with higher doses (1.0 g) of IVMP in consecutive days is associated with higher risk of liver damage than treatment with moderate doses (≤0.5 g) in every week schedule.
This trial is registered with NCT03667157.
American Psychological Association (APA)
Miśkiewicz, Piotr& Jankowska, Anna& Brodzińska, Kinga& Milczarek-Banach, Justyna& Ambroziak, Urszula. 2018. Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171118
Modern Language Association (MLA)
Miśkiewicz, Piotr…[et al.]. Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy. International Journal of Endocrinology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1171118
American Medical Association (AMA)
Miśkiewicz, Piotr& Jankowska, Anna& Brodzińska, Kinga& Milczarek-Banach, Justyna& Ambroziak, Urszula. Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171118