Effects of Cholecalciferol on Key Components of Vitamin D-EndoParaAutocrine System in Experimental Type 1 Diabetes
المؤلفون المشاركون
Mazanova, Anna
Shymanskyi, Ihor
Lisakovska, Olha
Hajiyeva, Lala
Komisarenko, Yulia
Veliky, Mykola
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives.
Recent prospective studies have found the associations between type 1 diabetes (T1D) and vitamin D deficiency.
We investigated the role of vitamin D in the regulation of 25OHD-1α-hydroxylase (CYP27B1) and VDR expression in different tissues of T1D rats.
Design.
T1D was induced in male Wistar rats by streptozotocin (55 mg/k b.w.).
After 2 weeks of T1D, the animals were treated orally with or without vitamin D3 (cholecalciferol; 100 IU/rat, 30 days).
Methods.
Serum 25-hydroxyvitamin D (25OHD) was detected by ELISA.
CYP27A1, CYP2R1, CYP27B1, and VDR were assayed by RT-qPCR and Western blotting or visualized by immunofluorescence staining.
Results.
We demonstrated that T1D led to a decrease in blood 25OHD, which is probably due to the established downregulation of CYP27A1 and CYP2R1 expression.
Vitamin D deficiency was accompanied by elevated synthesis of renal CYP27B1 and VDR.
Conversely, CYP27B1 and VDR expression decreased in the liver, bone tissue, and bone marrow.
Cholecalciferol administration countered the impairments of the vitamin D-endo/para/autocrine system in the kidneys and extrarenal tissues of diabetic rats.
Conclusions.
T1D-induced vitamin D deficiency is associated with impairments of renal and extrarenal CYP27B1 and VDR expression.
Cholecalciferol can be effective in the amelioration of diabetes-associated abnormalities in the vitamin D-endo/para/autocrine system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mazanova, Anna& Shymanskyi, Ihor& Lisakovska, Olha& Hajiyeva, Lala& Komisarenko, Yulia& Veliky, Mykola. 2018. Effects of Cholecalciferol on Key Components of Vitamin D-EndoParaAutocrine System in Experimental Type 1 Diabetes. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171174
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mazanova, Anna…[et al.]. Effects of Cholecalciferol on Key Components of Vitamin D-EndoParaAutocrine System in Experimental Type 1 Diabetes. International Journal of Endocrinology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1171174
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mazanova, Anna& Shymanskyi, Ihor& Lisakovska, Olha& Hajiyeva, Lala& Komisarenko, Yulia& Veliky, Mykola. Effects of Cholecalciferol on Key Components of Vitamin D-EndoParaAutocrine System in Experimental Type 1 Diabetes. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171174
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171174
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر