Long Noncoding RNA HOTTIP Serves as an Independent Predictive Biomarker for the Prognosis of Patients with Clear Cell Renal Cell Carcinoma
المؤلفون المشاركون
Liu, Zhanxin
Wang, Zichun
Wang, Xiaoxiong
Lu, Meisong
Chen, Guang
المصدر
International Journal of Genomics
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-14
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Several studies have indicated that HOXA transcript at the distal tip (HOTTIP) play important roles in the tumorigenesis and development of various cancers.
We aim to investigate the expression and prognostic value of HOTTIP in clear cell renal cell carcinoma (ccRCC).
A systematic review of PubMed, Embase, Medline, and Web of Science databases was performed to select eligible literatures relevant to the correlation between HOTTIP expression and clinical outcome of different cancers.
The association between the HOTTIP level and overall survival (OS), lymph node metastasis (LNM), or clinical stage was subsequently analyzed.
Survival analyses were performed in a large cohort of more than 500 patients with ccRCC from The Cancer Genome Atlas (TCGA) using bioinformatic methods.
Seventeen studies with a total of 1594 patients with thirteen kinds of carcinomas were included in this analysis.
The result showed that high HOTTIP expression could predict worse outcome in cancer patients, with the pooled hazard ratio (HR) of 2.34 (95% confidence interval (CI) 1.96–2.79, p<0.0001).
The result also showed that elevated HOTTIP expression was correlated with more LNM (OR=2.61, 95% CI 1.91-3.58, p<0.0001) and advanced clinical stage (OR=3.57, 95% CI 2.58-4.93, p<0.0001).
We further validated that ccRCC patients with higher HOTTIP expression tend to have unsatisfactory outcomes both in the entire TCGA dataset and different clinical stratums, like age, grade, and stage.
The tumor of those patients was associated with a larger size, easier to metastasis, advanced clinical stage, and a higher pathological grade.
These findings suggested that increased HOTTIP expression might act as a novel prognostic marker for ccRCC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Zhanxin& Wang, Zichun& Wang, Xiaoxiong& Lu, Meisong& Chen, Guang. 2020. Long Noncoding RNA HOTTIP Serves as an Independent Predictive Biomarker for the Prognosis of Patients with Clear Cell Renal Cell Carcinoma. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1171241
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Zhanxin…[et al.]. Long Noncoding RNA HOTTIP Serves as an Independent Predictive Biomarker for the Prognosis of Patients with Clear Cell Renal Cell Carcinoma. International Journal of Genomics No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1171241
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Zhanxin& Wang, Zichun& Wang, Xiaoxiong& Lu, Meisong& Chen, Guang. Long Noncoding RNA HOTTIP Serves as an Independent Predictive Biomarker for the Prognosis of Patients with Clear Cell Renal Cell Carcinoma. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1171241
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171241
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر