Long Noncoding RNA HOTTIP Serves as an Independent Predictive Biomarker for the Prognosis of Patients with Clear Cell Renal Cell Carcinoma
Joint Authors
Liu, Zhanxin
Wang, Zichun
Wang, Xiaoxiong
Lu, Meisong
Chen, Guang
Source
International Journal of Genomics
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Several studies have indicated that HOXA transcript at the distal tip (HOTTIP) play important roles in the tumorigenesis and development of various cancers.
We aim to investigate the expression and prognostic value of HOTTIP in clear cell renal cell carcinoma (ccRCC).
A systematic review of PubMed, Embase, Medline, and Web of Science databases was performed to select eligible literatures relevant to the correlation between HOTTIP expression and clinical outcome of different cancers.
The association between the HOTTIP level and overall survival (OS), lymph node metastasis (LNM), or clinical stage was subsequently analyzed.
Survival analyses were performed in a large cohort of more than 500 patients with ccRCC from The Cancer Genome Atlas (TCGA) using bioinformatic methods.
Seventeen studies with a total of 1594 patients with thirteen kinds of carcinomas were included in this analysis.
The result showed that high HOTTIP expression could predict worse outcome in cancer patients, with the pooled hazard ratio (HR) of 2.34 (95% confidence interval (CI) 1.96–2.79, p<0.0001).
The result also showed that elevated HOTTIP expression was correlated with more LNM (OR=2.61, 95% CI 1.91-3.58, p<0.0001) and advanced clinical stage (OR=3.57, 95% CI 2.58-4.93, p<0.0001).
We further validated that ccRCC patients with higher HOTTIP expression tend to have unsatisfactory outcomes both in the entire TCGA dataset and different clinical stratums, like age, grade, and stage.
The tumor of those patients was associated with a larger size, easier to metastasis, advanced clinical stage, and a higher pathological grade.
These findings suggested that increased HOTTIP expression might act as a novel prognostic marker for ccRCC patients.
American Psychological Association (APA)
Liu, Zhanxin& Wang, Zichun& Wang, Xiaoxiong& Lu, Meisong& Chen, Guang. 2020. Long Noncoding RNA HOTTIP Serves as an Independent Predictive Biomarker for the Prognosis of Patients with Clear Cell Renal Cell Carcinoma. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1171241
Modern Language Association (MLA)
Liu, Zhanxin…[et al.]. Long Noncoding RNA HOTTIP Serves as an Independent Predictive Biomarker for the Prognosis of Patients with Clear Cell Renal Cell Carcinoma. International Journal of Genomics No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1171241
American Medical Association (AMA)
Liu, Zhanxin& Wang, Zichun& Wang, Xiaoxiong& Lu, Meisong& Chen, Guang. Long Noncoding RNA HOTTIP Serves as an Independent Predictive Biomarker for the Prognosis of Patients with Clear Cell Renal Cell Carcinoma. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1171241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171241