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The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001
المؤلفون المشاركون
Tian, Kejian
Huo, Hongliang
Meng, Fanxing
Meng, Qi
Gao, Yan
Zhang, Lili
Wang, Le
Wang, Yuqing
Li, Xue
المصدر
International Journal of Genomics
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-26
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Estrogen contamination is recognized as one of the most serious environmental problems, causing widespread concern worldwide.
Environmental estrogens are mainly derived from human and vertebrate excretion, drugs, and agricultural activities.
The use of microorganisms is currently the most economical and effective method for biodegradation of environmental estrogens.
Rhodococcus equi DSSKP-R-001 (R-001) has strong estrogen-degrading capabilities.
Our study indicated that R-001 can use different types of estrogen as its sole carbon source for growth and metabolism, with final degradation rates above 90%.
Transcriptome analysis showed that 720 (E1), 983 (E2), and 845 (EE2) genes were significantly upregulated in the estrogen-treated group compared with the control group, and 270 differentially expressed genes (DEGs) were upregulated across all treatment groups.
These DEGs included ABC transporters; estrogen-degrading genes, including those that perform initial oxidation and dehydrogenation reactions and those that further degrade the resulting substrates into small molecules; and metabolism genes that complete the intracellular transformation and utilization of estrogen metabolites through biological processes such as amino acid metabolism, lipid metabolism, carbohydrate metabolism, and the tricarboxylic acid cycle.
In summary, the biodegradation of estrogens is coordinated by a metabolic network of estrogen-degrading enzymes, transporters, metabolic enzymes, and other coenzymes.
In this study, the metabolic mechanisms by which Rhodococcus equi R-001 degrades various estrogens were analyzed for the first time.
A new pollutant metabolism system is outlined, providing a starting point for the construction of engineered estrogen-degrading bacteria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Kejian& Meng, Fanxing& Meng, Qi& Gao, Yan& Zhang, Lili& Wang, Le…[et al.]. 2020. The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1171345
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Kejian…[et al.]. The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001. International Journal of Genomics No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1171345
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Kejian& Meng, Fanxing& Meng, Qi& Gao, Yan& Zhang, Lili& Wang, Le…[et al.]. The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1171345
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171345
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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