GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats
المؤلفون المشاركون
Li, Xiaozhong
Wang, Fengyun
Chen, Ting
Chen, Linqi
Xie, Rongrong
Sun, Hui
Wu, Haiying
Chen, Xiuli
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates.
The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated.
Methods.
The present study was aimed at longitudinally exploring whether the GnRHant could alleviate testicular damage induced by cyclophosphamide (CPA) in a rat model.
Pubertal male rats were assigned to receive CPA with and without GnRHant.
CPA was administrated at a single dose (100 mg/kg).
GnRHant was started one hour prior to CPA injection and continued for four weeks (0.1 mg/kg, 3 times a week).
Body and testes weights, testicular hormones, histological changes, and expression of androgen receptor (AR) in the testis were analyzed when rats matured into adulthood and completed a round of spermatogenesis.
Results.
Our results showed that body weight, histological injury, and AR expression in the testis were improved in the GnRHant + CPA group.
However, testes weight and testicular hormones (anti-Müllerian hormone, inhibin B, and testosterone) did not markedly change.
Conclusion.
Our results indicate that the GnRHant administration before and after CPA in pubertal rats can protect long-term testicular injury induced by CPA via increased AR expression in the testes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Rongrong& Chen, Linqi& Wu, Haiying& Chen, Ting& Wang, Fengyun& Chen, Xiuli…[et al.]. 2018. GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171358
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Rongrong…[et al.]. GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171358
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Rongrong& Chen, Linqi& Wu, Haiying& Chen, Ting& Wang, Fengyun& Chen, Xiuli…[et al.]. GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171358
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171358
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر