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GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats
Joint Authors
Li, Xiaozhong
Wang, Fengyun
Chen, Ting
Chen, Linqi
Xie, Rongrong
Sun, Hui
Wu, Haiying
Chen, Xiuli
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates.
The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated.
Methods.
The present study was aimed at longitudinally exploring whether the GnRHant could alleviate testicular damage induced by cyclophosphamide (CPA) in a rat model.
Pubertal male rats were assigned to receive CPA with and without GnRHant.
CPA was administrated at a single dose (100 mg/kg).
GnRHant was started one hour prior to CPA injection and continued for four weeks (0.1 mg/kg, 3 times a week).
Body and testes weights, testicular hormones, histological changes, and expression of androgen receptor (AR) in the testis were analyzed when rats matured into adulthood and completed a round of spermatogenesis.
Results.
Our results showed that body weight, histological injury, and AR expression in the testis were improved in the GnRHant + CPA group.
However, testes weight and testicular hormones (anti-Müllerian hormone, inhibin B, and testosterone) did not markedly change.
Conclusion.
Our results indicate that the GnRHant administration before and after CPA in pubertal rats can protect long-term testicular injury induced by CPA via increased AR expression in the testes.
American Psychological Association (APA)
Xie, Rongrong& Chen, Linqi& Wu, Haiying& Chen, Ting& Wang, Fengyun& Chen, Xiuli…[et al.]. 2018. GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171358
Modern Language Association (MLA)
Xie, Rongrong…[et al.]. GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171358
American Medical Association (AMA)
Xie, Rongrong& Chen, Linqi& Wu, Haiying& Chen, Ting& Wang, Fengyun& Chen, Xiuli…[et al.]. GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171358