Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance
المؤلفون المشاركون
Ping, Fan
Li, Yu-xiu
Zhou, Mei-cen
Li, Wei
Zhang, Huabing
He, Shuli
Zhu, Lixin
Cui, Xiangli
Feng, Linbo
Zhao, Xuefeng
Sun, Qi
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-05
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the association of polymorphisms in uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor (PPARγ) with glucolipid metabolism in Chinese Han population.
Methods.
Five hundred eighty-nine subjects were divided into normal glucose tolerance (NGT) group (n=198) and abnormal glucose tolerance group (n=358).
HbA1c, blood lipid profile, plasma glucose, and insulin were determined.
Insulin sensitivity (HOMA-IR and Matsuda index (ISIM)) and insulin secretion indexes (HOMA-β, early and total phase disposition index) were evaluated.
Eight potential functional SNPs in UCP2 and 7 in PPARγ were selected.
SNPs were genotyped on Sequenom MassARRAY platform.
Results.
The GG genotype of rs2920502 in PPARγ was associated with decreased risk of impaired glucose tolerance (G allele: OR: 0.818, 95%CI: 0.526–0.969, P=0.042; GG: OR: 0.715, 95%CI: 0.527–0.97, P=0.031).
The TT genotype of rs3856806 in PPARγ was associated with increased risk of impaired glucose tolerance (T allele: OR: 1.46, 95%CI: 1.055–2.017, P=0.022; TT: OR: 1.58, 95%CI: 1.104–2.761, P=0.032).
The GG genotype of rs2920502 in PPARγ had better blood glucose and increased insulin secretion and had lower HOMA-IR than GC/CC genotypes.
Conclusion.
It probably could prevent insulin resistance in early stage by classifying the genotype of rs649446 and rs7109266 in UCP2.
The GG genotype of rs2920502 in PPARγ had a decreased risk for diabetes.
The TT genotype of rs3856806 in PPARγ had an increased risk for diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Mei-cen& He, Shuli& Ping, Fan& Li, Wei& Zhu, Lixin& Cui, Xiangli…[et al.]. 2018. Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1171427
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Mei-cen…[et al.]. Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance. International Journal of Endocrinology No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1171427
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Mei-cen& He, Shuli& Ping, Fan& Li, Wei& Zhu, Lixin& Cui, Xiangli…[et al.]. Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1171427
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171427
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر