Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance

Abstract EN

Objective.

To investigate the association of polymorphisms in uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor (PPARγ) with glucolipid metabolism in Chinese Han population.

Methods.

Five hundred eighty-nine subjects were divided into normal glucose tolerance (NGT) group (n=198) and abnormal glucose tolerance group (n=358).

HbA1c, blood lipid profile, plasma glucose, and insulin were determined.

Insulin sensitivity (HOMA-IR and Matsuda index (ISIM)) and insulin secretion indexes (HOMA-β, early and total phase disposition index) were evaluated.

Eight potential functional SNPs in UCP2 and 7 in PPARγ were selected.

SNPs were genotyped on Sequenom MassARRAY platform.

Results.

The GG genotype of rs2920502 in PPARγ was associated with decreased risk of impaired glucose tolerance (G allele: OR: 0.818, 95%CI: 0.526–0.969, P=0.042; GG: OR: 0.715, 95%CI: 0.527–0.97, P=0.031).

The TT genotype of rs3856806 in PPARγ was associated with increased risk of impaired glucose tolerance (T allele: OR: 1.46, 95%CI: 1.055–2.017, P=0.022; TT: OR: 1.58, 95%CI: 1.104–2.761, P=0.032).

The GG genotype of rs2920502 in PPARγ had better blood glucose and increased insulin secretion and had lower HOMA-IR than GC/CC genotypes.

Conclusion.

It probably could prevent insulin resistance in early stage by classifying the genotype of rs649446 and rs7109266 in UCP2.

The GG genotype of rs2920502 in PPARγ had a decreased risk for diabetes.

The TT genotype of rs3856806 in PPARγ had an increased risk for diabetes.