Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level
المؤلفون المشاركون
Jia, Xiaowen
Zhang, Rong
Guo, Jinzhu
Yue, Hua
Liu, Qiuxia
Guo, Lipei
Zhang, Qunchang
المصدر
International Journal of Hypertension
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Pregnancy-induced hypertension (PIH) remains a major cause of morbidity and mortality in pregnancy worldwide.
This study was designed to study the blood pressure-lowering effect of resveratrol (RES) in a salt-induced hypertensive pregnant rat model.
Methods.
Forty female Sprague Dawley (SD) rats were randomized into 4 groups: Normal Preg (0.9% salt diet), Normal Preg + RES (0.9% salt diet plus daily oral RES for 4 weeks), Salt Preg (8% salt diet), and Salt Preg + RES (8% salt diet plus daily oral RES for 4 weeks).
Noninvasive blood pressure was recorded on gestational days 7 and 14.
On the gestational day 19, foetuses were weighed, and blood and urine samples were harvested for electrolytes and biochemical assays.
Results.
RES significantly reduced SBP, DBP, and MAP on gestational days 7 and 14 in the Salt Preg + RES group compared to the Salt Preg group (all P<0.05).
Compared to the Salt Preg group, the foetal weight, serum NO level, urinary sodium, and 24 hour urine volume were significantly increased in the Salt Preg + RES group (all P<0.05).
On the contrary, the levels of serum urea, serum creatinine, and urinary protein were significantly decreased in the Salt Preg + RES group compared to the Salt Preg group (all P<0.05).
Conclusions.
RES decreases blood pressure in a hypertensive pregnant rat model.
Increasing sodium excretion and serum nitric oxide level might be, at least part of, the underlying mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jia, Xiaowen& Zhang, Rong& Guo, Jinzhu& Yue, Hua& Liu, Qiuxia& Guo, Lipei…[et al.]. 2020. Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171627
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jia, Xiaowen…[et al.]. Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level. International Journal of Hypertension No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1171627
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jia, Xiaowen& Zhang, Rong& Guo, Jinzhu& Yue, Hua& Liu, Qiuxia& Guo, Lipei…[et al.]. Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171627
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171627
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر