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Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level
Joint Authors
Jia, Xiaowen
Zhang, Rong
Guo, Jinzhu
Yue, Hua
Liu, Qiuxia
Guo, Lipei
Zhang, Qunchang
Source
International Journal of Hypertension
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Pregnancy-induced hypertension (PIH) remains a major cause of morbidity and mortality in pregnancy worldwide.
This study was designed to study the blood pressure-lowering effect of resveratrol (RES) in a salt-induced hypertensive pregnant rat model.
Methods.
Forty female Sprague Dawley (SD) rats were randomized into 4 groups: Normal Preg (0.9% salt diet), Normal Preg + RES (0.9% salt diet plus daily oral RES for 4 weeks), Salt Preg (8% salt diet), and Salt Preg + RES (8% salt diet plus daily oral RES for 4 weeks).
Noninvasive blood pressure was recorded on gestational days 7 and 14.
On the gestational day 19, foetuses were weighed, and blood and urine samples were harvested for electrolytes and biochemical assays.
Results.
RES significantly reduced SBP, DBP, and MAP on gestational days 7 and 14 in the Salt Preg + RES group compared to the Salt Preg group (all P<0.05).
Compared to the Salt Preg group, the foetal weight, serum NO level, urinary sodium, and 24 hour urine volume were significantly increased in the Salt Preg + RES group (all P<0.05).
On the contrary, the levels of serum urea, serum creatinine, and urinary protein were significantly decreased in the Salt Preg + RES group compared to the Salt Preg group (all P<0.05).
Conclusions.
RES decreases blood pressure in a hypertensive pregnant rat model.
Increasing sodium excretion and serum nitric oxide level might be, at least part of, the underlying mechanisms.
American Psychological Association (APA)
Jia, Xiaowen& Zhang, Rong& Guo, Jinzhu& Yue, Hua& Liu, Qiuxia& Guo, Lipei…[et al.]. 2020. Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171627
Modern Language Association (MLA)
Jia, Xiaowen…[et al.]. Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level. International Journal of Hypertension No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1171627
American Medical Association (AMA)
Jia, Xiaowen& Zhang, Rong& Guo, Jinzhu& Yue, Hua& Liu, Qiuxia& Guo, Lipei…[et al.]. Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171627