Favorable Effect of Anti-TNF Therapy on Insulin Sensitivity in Nonobese, Nondiabetic Patients with Inflammatory Bowel Disease
المؤلفون المشاركون
Paschou, Stavroula A.
Kothonas, Fotios
Lafkas, Apostolos
Myroforidis, Alexandros
Loi, Vasiliki
Terzi, Thomais
Karagianni, Olympia
Poulou, Androniki
Goumas, Konstantinos
Vryonidou, Andromachi
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-05
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
The aim of this study was to investigate the effect of anti-TNF therapy on glucose and lipid metabolism in nondiabetic, nonobese patients with inflammatory bowel disease (IBD).
Patients and Methods.
We studied 44 patients with IBD, without a known history of diabetes.
Three of the patients were diagnosed with overt diabetes and were excluded.
Eighteen of the remaining patients (9 M/9 F, 33.6 ± 8.8 years) were on anti-TNF therapy for longer than 1 year, while 23 patients (16 M/7 F, 38.7 ± 12.5 years) were treated with aminosalicylates (AMSs).
Twelve of the patients from the second group were then treated with anti-TNF and reassessed 6 months later.
Fasting glucose, insulin, c-peptide, HbA1c, lipid, CRP, and fibrinogen levels were determined, and HOMA-IR index was calculated in all patients.
Results.
Patients from the two therapy groups were matched for age and BMI and were not obese.
We did not find any differences between patients from the two therapy groups regarding fasting glucose, c-peptide, HbA1c, total cholesterol, HDL, LDL, triglycerides, CRP, and HOMA-IR index.
In patients who were treated for 6 months with anti-TNF, a statistically significant decrease in insulin (before 15.5 ± 5.9 versus after 9.9 ± 2.9 μIU/ml, p=0.042) and c-peptide (before 2.4 ± 1 versus after 1.3 ± 0.4 ng/ml, p=0.030) levels as well as the HOMA-IR index (before 4.2 ± 1.9 versus after 2.2 ± 0.9, p=0.045) was observed, without any changes in weight, BMI, glucose, HbA1c, lipid, CRP, and fibrinogen levels.
Conclusion.
Anti-TNF therapy exerts a favorable effect on insulin sensitivity, while it has no effect on lipid levels in nondiabetic, nonobese patients with inflammatory bowel disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Paschou, Stavroula A.& Kothonas, Fotios& Lafkas, Apostolos& Myroforidis, Alexandros& Loi, Vasiliki& Terzi, Thomais…[et al.]. 2018. Favorable Effect of Anti-TNF Therapy on Insulin Sensitivity in Nonobese, Nondiabetic Patients with Inflammatory Bowel Disease. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1171834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Paschou, Stavroula A.…[et al.]. Favorable Effect of Anti-TNF Therapy on Insulin Sensitivity in Nonobese, Nondiabetic Patients with Inflammatory Bowel Disease. International Journal of Endocrinology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1171834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Paschou, Stavroula A.& Kothonas, Fotios& Lafkas, Apostolos& Myroforidis, Alexandros& Loi, Vasiliki& Terzi, Thomais…[et al.]. Favorable Effect of Anti-TNF Therapy on Insulin Sensitivity in Nonobese, Nondiabetic Patients with Inflammatory Bowel Disease. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1171834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر