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Favorable Effect of Anti-TNF Therapy on Insulin Sensitivity in Nonobese, Nondiabetic Patients with Inflammatory Bowel Disease
Joint Authors
Paschou, Stavroula A.
Kothonas, Fotios
Lafkas, Apostolos
Myroforidis, Alexandros
Loi, Vasiliki
Terzi, Thomais
Karagianni, Olympia
Poulou, Androniki
Goumas, Konstantinos
Vryonidou, Andromachi
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The aim of this study was to investigate the effect of anti-TNF therapy on glucose and lipid metabolism in nondiabetic, nonobese patients with inflammatory bowel disease (IBD).
Patients and Methods.
We studied 44 patients with IBD, without a known history of diabetes.
Three of the patients were diagnosed with overt diabetes and were excluded.
Eighteen of the remaining patients (9 M/9 F, 33.6 ± 8.8 years) were on anti-TNF therapy for longer than 1 year, while 23 patients (16 M/7 F, 38.7 ± 12.5 years) were treated with aminosalicylates (AMSs).
Twelve of the patients from the second group were then treated with anti-TNF and reassessed 6 months later.
Fasting glucose, insulin, c-peptide, HbA1c, lipid, CRP, and fibrinogen levels were determined, and HOMA-IR index was calculated in all patients.
Results.
Patients from the two therapy groups were matched for age and BMI and were not obese.
We did not find any differences between patients from the two therapy groups regarding fasting glucose, c-peptide, HbA1c, total cholesterol, HDL, LDL, triglycerides, CRP, and HOMA-IR index.
In patients who were treated for 6 months with anti-TNF, a statistically significant decrease in insulin (before 15.5 ± 5.9 versus after 9.9 ± 2.9 μIU/ml, p=0.042) and c-peptide (before 2.4 ± 1 versus after 1.3 ± 0.4 ng/ml, p=0.030) levels as well as the HOMA-IR index (before 4.2 ± 1.9 versus after 2.2 ± 0.9, p=0.045) was observed, without any changes in weight, BMI, glucose, HbA1c, lipid, CRP, and fibrinogen levels.
Conclusion.
Anti-TNF therapy exerts a favorable effect on insulin sensitivity, while it has no effect on lipid levels in nondiabetic, nonobese patients with inflammatory bowel disease.
American Psychological Association (APA)
Paschou, Stavroula A.& Kothonas, Fotios& Lafkas, Apostolos& Myroforidis, Alexandros& Loi, Vasiliki& Terzi, Thomais…[et al.]. 2018. Favorable Effect of Anti-TNF Therapy on Insulin Sensitivity in Nonobese, Nondiabetic Patients with Inflammatory Bowel Disease. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1171834
Modern Language Association (MLA)
Paschou, Stavroula A.…[et al.]. Favorable Effect of Anti-TNF Therapy on Insulin Sensitivity in Nonobese, Nondiabetic Patients with Inflammatory Bowel Disease. International Journal of Endocrinology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1171834
American Medical Association (AMA)
Paschou, Stavroula A.& Kothonas, Fotios& Lafkas, Apostolos& Myroforidis, Alexandros& Loi, Vasiliki& Terzi, Thomais…[et al.]. Favorable Effect of Anti-TNF Therapy on Insulin Sensitivity in Nonobese, Nondiabetic Patients with Inflammatory Bowel Disease. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1171834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171834