Circulating MicroRNAs in Elderly Type 2 Diabetic Patients
المؤلفون المشاركون
Dotta, Francesco
Besharat, Zein Mersini
Po, Agnese
Ferretti, Elisabetta
Catanzaro, Giuseppina
Chiacchiarini, Martina
Abballe, Luana
Sabato, Claudia
Vacca, Alessandra
Borgiani, Paola
Tesauro, Manfredi
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The circulating microRNAs (miRNAs) associated with type 2 diabetes (T2D) in elderly patients are still being defined.
To identify novel miRNA biomarker candidates for monitoring responses to sitagliptin in such patients, we prospectively studied 40 T2D patients (age > 65) with HbA1c levels of 7.5–9.0% on metformin.
After collection of baseline blood samples (t0), the dipeptidyl peptidase-IV (DPP-IV) inhibitor (DPP-IVi) sitagliptin was added to the metformin regimen, and patients were followed for 15 months.
Patients with HbA1c < 7.5% or HbA1c reduction > 0.5% after 3 and 15 months of therapy were classified as “responders” (group R, n=34); all others were classified as “nonresponders” (group NR, n=6).
Circulating miRNA profiling was performed on plasma collected in each group before and after 15 months of therapy (t0 and t15).
Intra- and intergroup comparison of miRNA profiles pinpointed three miRNAs that correlated with responses to sitagliptin: miR-378, which is a candidate biomarker of resistance to this DPP-IVi, and miR-126-3p and miR-223, which are associated with positive responses to the drug.
The translational implications are as immediate as evident, with the possibility to develop noninvasive diagnostic tools to predict drug response and development of chronic complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Catanzaro, Giuseppina& Besharat, Zein Mersini& Chiacchiarini, Martina& Abballe, Luana& Sabato, Claudia& Vacca, Alessandra…[et al.]. 2018. Circulating MicroRNAs in Elderly Type 2 Diabetic Patients. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1171846
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Catanzaro, Giuseppina…[et al.]. Circulating MicroRNAs in Elderly Type 2 Diabetic Patients. International Journal of Endocrinology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1171846
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Catanzaro, Giuseppina& Besharat, Zein Mersini& Chiacchiarini, Martina& Abballe, Luana& Sabato, Claudia& Vacca, Alessandra…[et al.]. Circulating MicroRNAs in Elderly Type 2 Diabetic Patients. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1171846
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171846
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر