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Circulating MicroRNAs in Elderly Type 2 Diabetic Patients
Joint Authors
Dotta, Francesco
Besharat, Zein Mersini
Po, Agnese
Ferretti, Elisabetta
Catanzaro, Giuseppina
Chiacchiarini, Martina
Abballe, Luana
Sabato, Claudia
Vacca, Alessandra
Borgiani, Paola
Tesauro, Manfredi
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The circulating microRNAs (miRNAs) associated with type 2 diabetes (T2D) in elderly patients are still being defined.
To identify novel miRNA biomarker candidates for monitoring responses to sitagliptin in such patients, we prospectively studied 40 T2D patients (age > 65) with HbA1c levels of 7.5–9.0% on metformin.
After collection of baseline blood samples (t0), the dipeptidyl peptidase-IV (DPP-IV) inhibitor (DPP-IVi) sitagliptin was added to the metformin regimen, and patients were followed for 15 months.
Patients with HbA1c < 7.5% or HbA1c reduction > 0.5% after 3 and 15 months of therapy were classified as “responders” (group R, n=34); all others were classified as “nonresponders” (group NR, n=6).
Circulating miRNA profiling was performed on plasma collected in each group before and after 15 months of therapy (t0 and t15).
Intra- and intergroup comparison of miRNA profiles pinpointed three miRNAs that correlated with responses to sitagliptin: miR-378, which is a candidate biomarker of resistance to this DPP-IVi, and miR-126-3p and miR-223, which are associated with positive responses to the drug.
The translational implications are as immediate as evident, with the possibility to develop noninvasive diagnostic tools to predict drug response and development of chronic complications.
American Psychological Association (APA)
Catanzaro, Giuseppina& Besharat, Zein Mersini& Chiacchiarini, Martina& Abballe, Luana& Sabato, Claudia& Vacca, Alessandra…[et al.]. 2018. Circulating MicroRNAs in Elderly Type 2 Diabetic Patients. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1171846
Modern Language Association (MLA)
Catanzaro, Giuseppina…[et al.]. Circulating MicroRNAs in Elderly Type 2 Diabetic Patients. International Journal of Endocrinology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1171846
American Medical Association (AMA)
Catanzaro, Giuseppina& Besharat, Zein Mersini& Chiacchiarini, Martina& Abballe, Luana& Sabato, Claudia& Vacca, Alessandra…[et al.]. Circulating MicroRNAs in Elderly Type 2 Diabetic Patients. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1171846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171846