Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity
المؤلفون المشاركون
Khalifa, Eman Aly
Nabil Ahmed, Ahmed
Hashem, Khalid Shaaban
Allah, Ahmad Gad
المصدر
International Journal of Inflammation
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Nephrotoxicity of cisplatin has been recognized since its introduction more than 25 years ago.
However, despite intense efforts to develop less toxic and equally effective alternatives, cisplatin continues to be widely prescribed.
Aim and Objectives.
The study is aimed at assessing the possible prophylactic effect of coenzyme Q10 (CoQ10) and alpha-lipoic acid (ALA) (separately or in combination) on experimentally cisplatin-induced nephrotoxicity.
Subjects and Methods.
An experimental study was performed on adult male albino rats (n = 40), weighing 200–250 g.
Rats were randomly divided into 5 groups: group I (normal saline control), group II (cisplatin control), group III (CoQ10 and cisplatin), group IV (ALA and cisplatin), and group V (CoQ10, ALA, and cisplatin).
CoQ10 and/or ALA were given as pretreatment for 9 days, followed by cisplatin injection in the 10th day of the study, followed by a short posttreatment course for 3 days.
Renal functions, tissue antioxidant activity, and inflammatory markers (tumor necrosis factor, TNF) were estimated along with histopathological study.
Results.
Renal function tests and urinary proteins were significantly higher within group II compared with other groups (P value <0.001).
Creatinine clearance was significantly higher with combination therapy (group V compared to other groups).
Both TNF and malondialdehyde (MDA) were significantly higher within group II whereas GSH content, catalase, and superoxide dismutase (SOD) were significantly lower in group II.
MDA level was significantly lower when combination therapy was used.
Marked renal damage was histologically detected in the cisplatin group, whereas the least renal damage was noticed in the combination group.
Conclusion.
The study confirmed the role of antioxidants in preventing nephrotoxicity caused by cisplatin; the prophylactic effect of combined therapy with CoQ10 and ALA is superior to that of monotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khalifa, Eman Aly& Nabil Ahmed, Ahmed& Hashem, Khalid Shaaban& Allah, Ahmad Gad. 2020. Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity. International Journal of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1171857
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khalifa, Eman Aly…[et al.]. Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity. International Journal of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1171857
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khalifa, Eman Aly& Nabil Ahmed, Ahmed& Hashem, Khalid Shaaban& Allah, Ahmad Gad. Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity. International Journal of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1171857
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171857
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر