Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity
Joint Authors
Khalifa, Eman Aly
Nabil Ahmed, Ahmed
Hashem, Khalid Shaaban
Allah, Ahmad Gad
Source
International Journal of Inflammation
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Nephrotoxicity of cisplatin has been recognized since its introduction more than 25 years ago.
However, despite intense efforts to develop less toxic and equally effective alternatives, cisplatin continues to be widely prescribed.
Aim and Objectives.
The study is aimed at assessing the possible prophylactic effect of coenzyme Q10 (CoQ10) and alpha-lipoic acid (ALA) (separately or in combination) on experimentally cisplatin-induced nephrotoxicity.
Subjects and Methods.
An experimental study was performed on adult male albino rats (n = 40), weighing 200–250 g.
Rats were randomly divided into 5 groups: group I (normal saline control), group II (cisplatin control), group III (CoQ10 and cisplatin), group IV (ALA and cisplatin), and group V (CoQ10, ALA, and cisplatin).
CoQ10 and/or ALA were given as pretreatment for 9 days, followed by cisplatin injection in the 10th day of the study, followed by a short posttreatment course for 3 days.
Renal functions, tissue antioxidant activity, and inflammatory markers (tumor necrosis factor, TNF) were estimated along with histopathological study.
Results.
Renal function tests and urinary proteins were significantly higher within group II compared with other groups (P value <0.001).
Creatinine clearance was significantly higher with combination therapy (group V compared to other groups).
Both TNF and malondialdehyde (MDA) were significantly higher within group II whereas GSH content, catalase, and superoxide dismutase (SOD) were significantly lower in group II.
MDA level was significantly lower when combination therapy was used.
Marked renal damage was histologically detected in the cisplatin group, whereas the least renal damage was noticed in the combination group.
Conclusion.
The study confirmed the role of antioxidants in preventing nephrotoxicity caused by cisplatin; the prophylactic effect of combined therapy with CoQ10 and ALA is superior to that of monotherapy.
American Psychological Association (APA)
Khalifa, Eman Aly& Nabil Ahmed, Ahmed& Hashem, Khalid Shaaban& Allah, Ahmad Gad. 2020. Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity. International Journal of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1171857
Modern Language Association (MLA)
Khalifa, Eman Aly…[et al.]. Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity. International Journal of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1171857
American Medical Association (AMA)
Khalifa, Eman Aly& Nabil Ahmed, Ahmed& Hashem, Khalid Shaaban& Allah, Ahmad Gad. Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity. International Journal of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1171857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171857