Assessment of Pathogenic Potential, Virulent Genes Profile, and Antibiotic Susceptibility of Proteus mirabilis from Urinary Tract Infection
المؤلفون المشاركون
Alzoubi, Karem H.
Hussein, Emad I.
Al-Batayneh, Khalid
Masadeh, Majed M.
Dahadhah, Fatina W.
Al Zoubi, Mazhar Salim
Aljabali, Alaa A.
المصدر
International Journal of Microbiology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-07
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Proteus mirabilis is the third most common bacterium that can cause complicated UTI, especially in catheterized patients.
Urovirulence genes of P.
mirabilis strains are poorly identified among UTI patients.
The aims of the present study were to determine the prevalence of the uropathogenic P.
mirabilis strains isolated from UTI patients by the detection of several P.
mirabilis virulence genes and to characterize the antibiotic susceptibility profile of P.
mirabilis isolates.
P.
mirabilis isolates were collected from urine specimens of patients suffering from UTI.
Virulence genes in P.
mirabilis, namely, hpmA, hpmB, rsbA, luxS, ureC1, hlyA, rpoA, atfA, atfC, mrpA, and pm1 were detected in the isolates via PCR detection method.
All P.
mirabilis virulence genes were detected in more than 90% of the isolates except hlyA gene, which was detected in only 23.8% of the isolates.
The rate of susceptibility for ceftriaxone was 96.8%, followed by norfloxacin (82.5%), gentamicin (71.4%), ciprofloxacin (69.8%), cephalexin (52.4%), nalidixic acid (42.9%), sulfamethoxazole (39.7%), ampicillin (36.5%), and nitrofurantoin (3.2%).
Significant associations (P<0.05) were detected between antimicrobial susceptibility of each of the following antibiotics and the presence virulence genes.
Cephalexin antimicrobial susceptibility was significantly associated with the presence each of ureC1 and atfC.
Sulfamethoxazole antimicrobial susceptibility was significantly associated with the presence atfA.
Ceftriaxone antimicrobial susceptibility was significantly associated with the presence each of hpmA, ureC1, rpoA, atfC, mrpA, and pm1.
Nitrofurantoin antimicrobial susceptibility was significantly associated with the presence each of hpmA, ureC1, rpoA, atfA, atfC, mrpA, and pm1.
In conclusion, an association between the presence of urovirulence genes of P.
mirabilis and increasing P.
mirabilis resistance to antimicrobials has been demonstrated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hussein, Emad I.& Al-Batayneh, Khalid& Masadeh, Majed M.& Dahadhah, Fatina W.& Al Zoubi, Mazhar Salim& Aljabali, Alaa A.…[et al.]. 2020. Assessment of Pathogenic Potential, Virulent Genes Profile, and Antibiotic Susceptibility of Proteus mirabilis from Urinary Tract Infection. International Journal of Microbiology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1171968
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hussein, Emad I.…[et al.]. Assessment of Pathogenic Potential, Virulent Genes Profile, and Antibiotic Susceptibility of Proteus mirabilis from Urinary Tract Infection. International Journal of Microbiology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1171968
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hussein, Emad I.& Al-Batayneh, Khalid& Masadeh, Majed M.& Dahadhah, Fatina W.& Al Zoubi, Mazhar Salim& Aljabali, Alaa A.…[et al.]. Assessment of Pathogenic Potential, Virulent Genes Profile, and Antibiotic Susceptibility of Proteus mirabilis from Urinary Tract Infection. International Journal of Microbiology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1171968
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171968
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر