Assessment of Pathogenic Potential, Virulent Genes Profile, and Antibiotic Susceptibility of Proteus mirabilis from Urinary Tract Infection
Joint Authors
Alzoubi, Karem H.
Hussein, Emad I.
Al-Batayneh, Khalid
Masadeh, Majed M.
Dahadhah, Fatina W.
Al Zoubi, Mazhar Salim
Aljabali, Alaa A.
Source
International Journal of Microbiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Proteus mirabilis is the third most common bacterium that can cause complicated UTI, especially in catheterized patients.
Urovirulence genes of P.
mirabilis strains are poorly identified among UTI patients.
The aims of the present study were to determine the prevalence of the uropathogenic P.
mirabilis strains isolated from UTI patients by the detection of several P.
mirabilis virulence genes and to characterize the antibiotic susceptibility profile of P.
mirabilis isolates.
P.
mirabilis isolates were collected from urine specimens of patients suffering from UTI.
Virulence genes in P.
mirabilis, namely, hpmA, hpmB, rsbA, luxS, ureC1, hlyA, rpoA, atfA, atfC, mrpA, and pm1 were detected in the isolates via PCR detection method.
All P.
mirabilis virulence genes were detected in more than 90% of the isolates except hlyA gene, which was detected in only 23.8% of the isolates.
The rate of susceptibility for ceftriaxone was 96.8%, followed by norfloxacin (82.5%), gentamicin (71.4%), ciprofloxacin (69.8%), cephalexin (52.4%), nalidixic acid (42.9%), sulfamethoxazole (39.7%), ampicillin (36.5%), and nitrofurantoin (3.2%).
Significant associations (P<0.05) were detected between antimicrobial susceptibility of each of the following antibiotics and the presence virulence genes.
Cephalexin antimicrobial susceptibility was significantly associated with the presence each of ureC1 and atfC.
Sulfamethoxazole antimicrobial susceptibility was significantly associated with the presence atfA.
Ceftriaxone antimicrobial susceptibility was significantly associated with the presence each of hpmA, ureC1, rpoA, atfC, mrpA, and pm1.
Nitrofurantoin antimicrobial susceptibility was significantly associated with the presence each of hpmA, ureC1, rpoA, atfA, atfC, mrpA, and pm1.
In conclusion, an association between the presence of urovirulence genes of P.
mirabilis and increasing P.
mirabilis resistance to antimicrobials has been demonstrated.
American Psychological Association (APA)
Hussein, Emad I.& Al-Batayneh, Khalid& Masadeh, Majed M.& Dahadhah, Fatina W.& Al Zoubi, Mazhar Salim& Aljabali, Alaa A.…[et al.]. 2020. Assessment of Pathogenic Potential, Virulent Genes Profile, and Antibiotic Susceptibility of Proteus mirabilis from Urinary Tract Infection. International Journal of Microbiology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1171968
Modern Language Association (MLA)
Hussein, Emad I.…[et al.]. Assessment of Pathogenic Potential, Virulent Genes Profile, and Antibiotic Susceptibility of Proteus mirabilis from Urinary Tract Infection. International Journal of Microbiology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1171968
American Medical Association (AMA)
Hussein, Emad I.& Al-Batayneh, Khalid& Masadeh, Majed M.& Dahadhah, Fatina W.& Al Zoubi, Mazhar Salim& Aljabali, Alaa A.…[et al.]. Assessment of Pathogenic Potential, Virulent Genes Profile, and Antibiotic Susceptibility of Proteus mirabilis from Urinary Tract Infection. International Journal of Microbiology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1171968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171968