Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl HydrazineHydrazone Derivatives

الملخص EN

1,3,5-Triazines and pyrimidine-2,4,6-triones belong to that class of compounds which are well known in literature for possessing wide range of biological activities.

Here, we report a new family of compounds that encompasses these two structures.

The union of both heterocycles was carried out through a hydrazone moiety incorporated into an acetyl group at the position 5 of 1,3-dimethyl pyrimidine derivative.

The synthetic strategy adopted allowed the preparation of the target compounds with excellent yields and good purities.

The synthesized compounds were well characterized by NMR (1H and 13C), HRMS, and elemental analysis.

Furthermore, the tautomerism of enhydrazine versus hydrazone has also been studied.