Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in obob Mice
المؤلفون المشاركون
Zeng, Tian-shu
Chen, Lu-lu
Zheng, Wenbin
Zhou, Jing
Song, Shasha
Kong, Wen
Xia, Wenfang
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Obesity and type 2 diabetes are the most common metabolic diseases globally.
They are associated with inflammation, oxidative stress, autophagy, and insulin resistance.
Sitagliptin, a dipeptidyl-peptidase 4 inhibitor, has been reported to show multiple biological activities beyond the antidiabetic property.
This study was aimed at investigating the effect of sitagliptin on hepatic steatosis, insulin resistance, inflammation, and autophagy and exploring the underlying molecular mechanism.
In the current study, ob/ob mice, a mouse model of genetic obesity and diabetes, were administered via gavage with sitagliptin 50 mg/kg daily for 4 weeks.
Changes in glycolipid metabolism, inflammatory responses, and autophagy in the liver were evaluated.
Body weight gain, lipid metabolic disorder, and hepatic steatosis as well as systemic and hepatic insulin sensitivity in ob/ob mice were significantly attenuated after sitagliptin treatment.
Furthermore, sitagliptin decreased inflammatory responses by regulating macrophage M1/M2 polarization and inhibiting the activities of NF-κB and JNK.
Moreover, sitagliptin increased the levels of phosphorylation of AMPK and decreased those of mTOR.
This study indicates that sitagliptin significantly ameliorates the development of hepatic steatosis and insulin resistance in ob/ob mice by inhibiting inflammatory responses and activating autophagy via AMPK/mTOR signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Wenbin& Zhou, Jing& Song, Shasha& Kong, Wen& Xia, Wenfang& Chen, Lu-lu…[et al.]. 2018. Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in obob Mice. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1172137
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Wenbin…[et al.]. Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in obob Mice. International Journal of Endocrinology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1172137
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Wenbin& Zhou, Jing& Song, Shasha& Kong, Wen& Xia, Wenfang& Chen, Lu-lu…[et al.]. Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in obob Mice. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1172137
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172137
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر