Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in obob Mice
Joint Authors
Zeng, Tian-shu
Chen, Lu-lu
Zheng, Wenbin
Zhou, Jing
Song, Shasha
Kong, Wen
Xia, Wenfang
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Obesity and type 2 diabetes are the most common metabolic diseases globally.
They are associated with inflammation, oxidative stress, autophagy, and insulin resistance.
Sitagliptin, a dipeptidyl-peptidase 4 inhibitor, has been reported to show multiple biological activities beyond the antidiabetic property.
This study was aimed at investigating the effect of sitagliptin on hepatic steatosis, insulin resistance, inflammation, and autophagy and exploring the underlying molecular mechanism.
In the current study, ob/ob mice, a mouse model of genetic obesity and diabetes, were administered via gavage with sitagliptin 50 mg/kg daily for 4 weeks.
Changes in glycolipid metabolism, inflammatory responses, and autophagy in the liver were evaluated.
Body weight gain, lipid metabolic disorder, and hepatic steatosis as well as systemic and hepatic insulin sensitivity in ob/ob mice were significantly attenuated after sitagliptin treatment.
Furthermore, sitagliptin decreased inflammatory responses by regulating macrophage M1/M2 polarization and inhibiting the activities of NF-κB and JNK.
Moreover, sitagliptin increased the levels of phosphorylation of AMPK and decreased those of mTOR.
This study indicates that sitagliptin significantly ameliorates the development of hepatic steatosis and insulin resistance in ob/ob mice by inhibiting inflammatory responses and activating autophagy via AMPK/mTOR signaling pathway.
American Psychological Association (APA)
Zheng, Wenbin& Zhou, Jing& Song, Shasha& Kong, Wen& Xia, Wenfang& Chen, Lu-lu…[et al.]. 2018. Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in obob Mice. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1172137
Modern Language Association (MLA)
Zheng, Wenbin…[et al.]. Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in obob Mice. International Journal of Endocrinology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1172137
American Medical Association (AMA)
Zheng, Wenbin& Zhou, Jing& Song, Shasha& Kong, Wen& Xia, Wenfang& Chen, Lu-lu…[et al.]. Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in obob Mice. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1172137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172137