Age-Related Cutoffs of Plasma AldosteroneRenin Concentration for Primary Aldosteronism Screening
المؤلفون المشاركون
Song, Ying
Mei, Mei
He, Wenwen
Hu, Jinbo
Tang, Ziwei
Luo, Ting
Wang, Yue
Zhen, Qianna
Wang, Zhihong
Qing, Hua
He, Yihong
Fahey, Thomas J.
Ma, Linqiang
Yang, Shumin
Cheng, Qingfeng
Li, Qifu
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
This retrospective study is aimed at investigating whether aldosterone-renin ratio (ARR) cutoffs calculated by the plasma aldosterone concentration (PAC)/plasma renin concentration (PRC) should be set differently in patients of different ages.
Methods.
521 hypertensive patients were screened for primary aldosteronism (PA) by the PAC/PRC.
174 patients diagnosed with PA and 311 patients with essential hypertension (EH) were included in the final analysis.
Subjects were subdivided into four age groups: <40, 40–49, 50–59, and ≥60 years old.
Results.
The accuracy of the ARR varied greatly among the different age groups.
An ARR of 3.7 (ng/dl)/(μIU/ml) had a sensitivity of 100% and a specificity of 80% in patients ≥ 60 years old.
With this cutoff, the sensitivities in patients < 40, 40–49, and 50–59 years old were 74%, 82%, and 87%, respectively, and the specificities were 94%, 95%, and 94%, respectively.
To achieve a sensitivity higher than 90%, the ARR cutoff needed to be lowered to 2.0 (ng/dl)/(μIU/ml) for patients 40–49 and 50–59 years old, resulting in sensitivities of 90% and 95%, respectively, and specificities of 80% and 84%, respectively.
To achieve a sensitivity higher than 90%, the ARR cutoff needed to be lowered to 1.0 (ng/dl)/(μIU/ml) for patients < 40 years old, resulting in a sensitivity of 90% and a specificity of 82%.
Conclusions.
An ARR of 3.7 (ng/dl)/(μIU/ml) is optimal for patients ≥ 60 years; for patients 40–59 years, the optimal ARR cutoff is 2.0; for those younger than 40 years, an ARR of 1.0 may be more reasonable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Linqiang& Song, Ying& Mei, Mei& He, Wenwen& Hu, Jinbo& Cheng, Qingfeng…[et al.]. 2018. Age-Related Cutoffs of Plasma AldosteroneRenin Concentration for Primary Aldosteronism Screening. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172215
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Linqiang…[et al.]. Age-Related Cutoffs of Plasma AldosteroneRenin Concentration for Primary Aldosteronism Screening. International Journal of Endocrinology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1172215
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Linqiang& Song, Ying& Mei, Mei& He, Wenwen& Hu, Jinbo& Cheng, Qingfeng…[et al.]. Age-Related Cutoffs of Plasma AldosteroneRenin Concentration for Primary Aldosteronism Screening. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172215
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172215
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر