Age-Related Cutoffs of Plasma AldosteroneRenin Concentration for Primary Aldosteronism Screening
Joint Authors
Song, Ying
Mei, Mei
He, Wenwen
Hu, Jinbo
Tang, Ziwei
Luo, Ting
Wang, Yue
Zhen, Qianna
Wang, Zhihong
Qing, Hua
He, Yihong
Fahey, Thomas J.
Ma, Linqiang
Yang, Shumin
Cheng, Qingfeng
Li, Qifu
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
This retrospective study is aimed at investigating whether aldosterone-renin ratio (ARR) cutoffs calculated by the plasma aldosterone concentration (PAC)/plasma renin concentration (PRC) should be set differently in patients of different ages.
Methods.
521 hypertensive patients were screened for primary aldosteronism (PA) by the PAC/PRC.
174 patients diagnosed with PA and 311 patients with essential hypertension (EH) were included in the final analysis.
Subjects were subdivided into four age groups: <40, 40–49, 50–59, and ≥60 years old.
Results.
The accuracy of the ARR varied greatly among the different age groups.
An ARR of 3.7 (ng/dl)/(μIU/ml) had a sensitivity of 100% and a specificity of 80% in patients ≥ 60 years old.
With this cutoff, the sensitivities in patients < 40, 40–49, and 50–59 years old were 74%, 82%, and 87%, respectively, and the specificities were 94%, 95%, and 94%, respectively.
To achieve a sensitivity higher than 90%, the ARR cutoff needed to be lowered to 2.0 (ng/dl)/(μIU/ml) for patients 40–49 and 50–59 years old, resulting in sensitivities of 90% and 95%, respectively, and specificities of 80% and 84%, respectively.
To achieve a sensitivity higher than 90%, the ARR cutoff needed to be lowered to 1.0 (ng/dl)/(μIU/ml) for patients < 40 years old, resulting in a sensitivity of 90% and a specificity of 82%.
Conclusions.
An ARR of 3.7 (ng/dl)/(μIU/ml) is optimal for patients ≥ 60 years; for patients 40–59 years, the optimal ARR cutoff is 2.0; for those younger than 40 years, an ARR of 1.0 may be more reasonable.
American Psychological Association (APA)
Ma, Linqiang& Song, Ying& Mei, Mei& He, Wenwen& Hu, Jinbo& Cheng, Qingfeng…[et al.]. 2018. Age-Related Cutoffs of Plasma AldosteroneRenin Concentration for Primary Aldosteronism Screening. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172215
Modern Language Association (MLA)
Ma, Linqiang…[et al.]. Age-Related Cutoffs of Plasma AldosteroneRenin Concentration for Primary Aldosteronism Screening. International Journal of Endocrinology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1172215
American Medical Association (AMA)
Ma, Linqiang& Song, Ying& Mei, Mei& He, Wenwen& Hu, Jinbo& Cheng, Qingfeng…[et al.]. Age-Related Cutoffs of Plasma AldosteroneRenin Concentration for Primary Aldosteronism Screening. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172215