Synthesis and Anticancer Activities of 4-[(Halophenyl)‎diazenyl]phenol and 4-[(Halophenyl)‎diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines

المؤلفون المشاركون

Ngaini, Zainab
Hwang, Siaw San
Ho, Boon Kui
Matthew Neilsen, Paul
Entigu Linton, Reagan
Kong, Ee Ling
Lee, Boon Kiat

المصدر

Journal of Chemistry

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-07-25

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الكيمياء

الملخص EN

Aspirin and azo derivatives have been widely studied and have drawn considerable attention due to diverse biological activities.

In this study, a series of 4-[(halophenyl)diazenyl]phenyl aspirinate derivatives were synthesized from the reaction of aspirin with 4-[(halophenyl)diazenyl]phenol via esterification, in the presence of DCC/DMAP in DCM with overall yield of 45–54%.

4-[(Halophenyl)diazenyl]phenol was prepared prior to esterification from coupling reaction of aniline derivatives and phenol in basic solution.

All compounds were characterized using elemental analysis, FTIR, and 1H and 13C NMR spectroscopies.

All compounds were screened for their anticancer activities against nasopharyngeal cancer (NPC) HK-1 cell lines and the viability of cultured cells was determined by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxylmethoxylphenyl)-2-(4-sulfophenyl)-2H-tetrazolium]-based colorimetric assay.

4-[(E)-(Fluorophenyl)diazenyl]phenol showed the highest anticancer activity against NPC HK-1 cell lines compared to other synthesized compounds.

4-[(Halophenyl)diazenyl]phenyl aspirinate showed low cytotoxicity against NPC HK-1 cell lines compared to 4-[(halophenyl)diazenyl]phenol but better anticancer activity than aspirin alone.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ho, Boon Kui& Ngaini, Zainab& Matthew Neilsen, Paul& Hwang, Siaw San& Entigu Linton, Reagan& Kong, Ee Ling…[et al.]. 2017. Synthesis and Anticancer Activities of 4-[(Halophenyl)diazenyl]phenol and 4-[(Halophenyl)diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1172237

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ho, Boon Kui…[et al.]. Synthesis and Anticancer Activities of 4-[(Halophenyl)diazenyl]phenol and 4-[(Halophenyl)diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines. Journal of Chemistry No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1172237

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ho, Boon Kui& Ngaini, Zainab& Matthew Neilsen, Paul& Hwang, Siaw San& Entigu Linton, Reagan& Kong, Ee Ling…[et al.]. Synthesis and Anticancer Activities of 4-[(Halophenyl)diazenyl]phenol and 4-[(Halophenyl)diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1172237

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1172237