Synthesis and Anticancer Activities of 4-[(Halophenyl)diazenyl]phenol and 4-[(Halophenyl)diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines
Joint Authors
Ngaini, Zainab
Hwang, Siaw San
Ho, Boon Kui
Matthew Neilsen, Paul
Entigu Linton, Reagan
Kong, Ee Ling
Lee, Boon Kiat
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aspirin and azo derivatives have been widely studied and have drawn considerable attention due to diverse biological activities.
In this study, a series of 4-[(halophenyl)diazenyl]phenyl aspirinate derivatives were synthesized from the reaction of aspirin with 4-[(halophenyl)diazenyl]phenol via esterification, in the presence of DCC/DMAP in DCM with overall yield of 45–54%.
4-[(Halophenyl)diazenyl]phenol was prepared prior to esterification from coupling reaction of aniline derivatives and phenol in basic solution.
All compounds were characterized using elemental analysis, FTIR, and 1H and 13C NMR spectroscopies.
All compounds were screened for their anticancer activities against nasopharyngeal cancer (NPC) HK-1 cell lines and the viability of cultured cells was determined by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxylmethoxylphenyl)-2-(4-sulfophenyl)-2H-tetrazolium]-based colorimetric assay.
4-[(E)-(Fluorophenyl)diazenyl]phenol showed the highest anticancer activity against NPC HK-1 cell lines compared to other synthesized compounds.
4-[(Halophenyl)diazenyl]phenyl aspirinate showed low cytotoxicity against NPC HK-1 cell lines compared to 4-[(halophenyl)diazenyl]phenol but better anticancer activity than aspirin alone.
American Psychological Association (APA)
Ho, Boon Kui& Ngaini, Zainab& Matthew Neilsen, Paul& Hwang, Siaw San& Entigu Linton, Reagan& Kong, Ee Ling…[et al.]. 2017. Synthesis and Anticancer Activities of 4-[(Halophenyl)diazenyl]phenol and 4-[(Halophenyl)diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1172237
Modern Language Association (MLA)
Ho, Boon Kui…[et al.]. Synthesis and Anticancer Activities of 4-[(Halophenyl)diazenyl]phenol and 4-[(Halophenyl)diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines. Journal of Chemistry No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1172237
American Medical Association (AMA)
Ho, Boon Kui& Ngaini, Zainab& Matthew Neilsen, Paul& Hwang, Siaw San& Entigu Linton, Reagan& Kong, Ee Ling…[et al.]. Synthesis and Anticancer Activities of 4-[(Halophenyl)diazenyl]phenol and 4-[(Halophenyl)diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1172237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172237