Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA)
المؤلفون المشاركون
Nasir, Shumyila
Vohra, Muhammad Sufyan
Gul, Danish
Swaiba, Umm E
Aleem, Maira
Mehmood, Khalid
Andleeb, Saadia
المصدر
International Journal of Microbiology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The emergence of multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), the chief etiological agent for a range of refractory infections, has rendered all β-lactams ineffective against it.
The treatment process is further complicated with the development of resistance to glycopeptides, primary antibiotics for treatment of MRSA.
Antibiotic combination therapy with existing antimicrobial agents may provide an immediate treatment option.
Minimum inhibitory concentrations (MICs) of 18 different commercially available antibiotics were determined along with their 90 possible pairwise combinations and 64 triple combinations to filter out 5 best combinations.
Time-Kill kinetics of these combinations were then analyzed to find collateral bactericidal combinations which were then tested on other randomly selected MRSA isolates.
Among the top 5 combinations including levofloxacin-ceftazidime; amoxicillin/clavulanic acid-tobramycin; amoxicillin/clavulanic acid-cephradine; amoxicillin/clavulanic acid-ofloxacin; and piperacillin/tazobactam-tobramycin, three combinations were found to be collaterally effective.
Levofloxacin-ceftazidime acted synergistically in 80% of the tested clinical MRSA isolates.
First-line β-lactams of lower generations can be used effectively against MRSA infection when used in combination.
Antibiotics other than glycopeptides may still work in combination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nasir, Shumyila& Vohra, Muhammad Sufyan& Gul, Danish& Swaiba, Umm E& Aleem, Maira& Mehmood, Khalid…[et al.]. 2020. Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA). International Journal of Microbiology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1172363
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nasir, Shumyila…[et al.]. Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA). International Journal of Microbiology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1172363
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nasir, Shumyila& Vohra, Muhammad Sufyan& Gul, Danish& Swaiba, Umm E& Aleem, Maira& Mehmood, Khalid…[et al.]. Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA). International Journal of Microbiology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1172363
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172363
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر