Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA)
Joint Authors
Nasir, Shumyila
Vohra, Muhammad Sufyan
Gul, Danish
Swaiba, Umm E
Aleem, Maira
Mehmood, Khalid
Andleeb, Saadia
Source
International Journal of Microbiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The emergence of multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), the chief etiological agent for a range of refractory infections, has rendered all β-lactams ineffective against it.
The treatment process is further complicated with the development of resistance to glycopeptides, primary antibiotics for treatment of MRSA.
Antibiotic combination therapy with existing antimicrobial agents may provide an immediate treatment option.
Minimum inhibitory concentrations (MICs) of 18 different commercially available antibiotics were determined along with their 90 possible pairwise combinations and 64 triple combinations to filter out 5 best combinations.
Time-Kill kinetics of these combinations were then analyzed to find collateral bactericidal combinations which were then tested on other randomly selected MRSA isolates.
Among the top 5 combinations including levofloxacin-ceftazidime; amoxicillin/clavulanic acid-tobramycin; amoxicillin/clavulanic acid-cephradine; amoxicillin/clavulanic acid-ofloxacin; and piperacillin/tazobactam-tobramycin, three combinations were found to be collaterally effective.
Levofloxacin-ceftazidime acted synergistically in 80% of the tested clinical MRSA isolates.
First-line β-lactams of lower generations can be used effectively against MRSA infection when used in combination.
Antibiotics other than glycopeptides may still work in combination.
American Psychological Association (APA)
Nasir, Shumyila& Vohra, Muhammad Sufyan& Gul, Danish& Swaiba, Umm E& Aleem, Maira& Mehmood, Khalid…[et al.]. 2020. Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA). International Journal of Microbiology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1172363
Modern Language Association (MLA)
Nasir, Shumyila…[et al.]. Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA). International Journal of Microbiology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1172363
American Medical Association (AMA)
Nasir, Shumyila& Vohra, Muhammad Sufyan& Gul, Danish& Swaiba, Umm E& Aleem, Maira& Mehmood, Khalid…[et al.]. Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA). International Journal of Microbiology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1172363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172363