A Simple and Improved HPLC-PDA Method for Simultaneous Estimation of Fexofenadine and Pseudoephedrine in Extended Release Tablets by Response Surface Methodology
المؤلفون المشاركون
Kayesh, Ruhul
Sarker, A. S. M. Moniruzzaman
Sultan, Md. Zakir
Jahan, Md. Sarowar
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
A simple RP-HPLC method has been developed for simultaneous estimation of fexofenadine and pseudoephedrine in their extended release tablet.
The method was developed based on statistical design of experiments (DoE) and Response Surface Methodology.
Separation was achieved on double end-capped C18 column (250 mm × 4 mm, 5 μm).
In this experiment, two components of mobile phase, namely, acetonitrile (% v/v) and methanol (% v/v), were the factors whereas retention and resolution of the chromatographic peaks were the responses.
The effects of different composition of factors on the corresponding responses were investigated.
The optimum chromatographic condition for the current case was found as an isocratic mobile phase consisting of 20 mM phosphate buffer (pH 6.8) and acetonitrile and methanol in a ratio of 50 : 36 : 14 (% v/v) at a flow rate of 1 mL/min for 7 minutes.
The retention of pseudoephedrine and fexofenadine was found to be 2.6 min and 4.7 min, respectively.
The method was validated according to the ICH and FDA guidelines and various validation parameters were determined.
Also, forced degradation studies in acid, base, oxidation, and reduction media and in thermal condition were performed to establish specificity and stability-indicating property of this method.
Practical applicability of this method was checked in extended release tablets available in Bangladeshi market.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kayesh, Ruhul& Sarker, A. S. M. Moniruzzaman& Sultan, Md. Zakir& Jahan, Md. Sarowar. 2017. A Simple and Improved HPLC-PDA Method for Simultaneous Estimation of Fexofenadine and Pseudoephedrine in Extended Release Tablets by Response Surface Methodology. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1172587
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kayesh, Ruhul…[et al.]. A Simple and Improved HPLC-PDA Method for Simultaneous Estimation of Fexofenadine and Pseudoephedrine in Extended Release Tablets by Response Surface Methodology. Journal of Chemistry No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1172587
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kayesh, Ruhul& Sarker, A. S. M. Moniruzzaman& Sultan, Md. Zakir& Jahan, Md. Sarowar. A Simple and Improved HPLC-PDA Method for Simultaneous Estimation of Fexofenadine and Pseudoephedrine in Extended Release Tablets by Response Surface Methodology. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1172587
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172587
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر