Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions

المؤلفون المشاركون

He, Sha
Ou, Haiyan
Zhao, Cunyou
Zhang, Jian

المصدر

International Journal of Genomics

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-4، 4ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-03-06

دولة النشر

مصر

عدد الصفحات

4

التخصصات الرئيسية

الأحياء

الملخص EN

miRNAs are a class of noncoding RNAs important in posttranscriptional repressors and involved in the regulation of almost every biological process by base paring with target genes through sequence in their seed regions.

Genetic variations in the seed regions have vital effects on gene expression, phenotypic variation, and disease susceptibility in humans.

The distribution pattern of genetic variation in miRNA seed regions might be related to miRNA function and is worth paying more attention to.

We here employed computational analyses to explore the clustering pattern and functional effect of SNPs in human miRNA seed regions.

A total of 1879 SNPs were mapped to 1226 human miRNA seed regions.

We found that miRNAs with SNPs in their seed region are significantly enriched in miRNA clusters.

We also found that SNPs in clustered miRNA seed regions have a lower functional effect than have SNPs in nonclustered miRNA seed regions.

Additionally, we found that clustered miRNAs with SNPs in seed regions are involved in more pathways.

Overall, our results demonstrate that SNPs in clustered miRNA seed regions can take part in more intricate and complex gene-regulating networks with lower functional cost by functional complementarity.

Moreover, our results also broaden current knowledge on the genetic variation in human miRNA seed regions.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

He, Sha& Ou, Haiyan& Zhao, Cunyou& Zhang, Jian. 2018. Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1172697

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

He, Sha…[et al.]. Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions. International Journal of Genomics No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1172697

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

He, Sha& Ou, Haiyan& Zhao, Cunyou& Zhang, Jian. Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1172697

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1172697