Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions

Joint Authors

He, Sha
Ou, Haiyan
Zhao, Cunyou
Zhang, Jian

Source

International Journal of Genomics

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-03-06

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Biology

Abstract EN

miRNAs are a class of noncoding RNAs important in posttranscriptional repressors and involved in the regulation of almost every biological process by base paring with target genes through sequence in their seed regions.

Genetic variations in the seed regions have vital effects on gene expression, phenotypic variation, and disease susceptibility in humans.

The distribution pattern of genetic variation in miRNA seed regions might be related to miRNA function and is worth paying more attention to.

We here employed computational analyses to explore the clustering pattern and functional effect of SNPs in human miRNA seed regions.

A total of 1879 SNPs were mapped to 1226 human miRNA seed regions.

We found that miRNAs with SNPs in their seed region are significantly enriched in miRNA clusters.

We also found that SNPs in clustered miRNA seed regions have a lower functional effect than have SNPs in nonclustered miRNA seed regions.

Additionally, we found that clustered miRNAs with SNPs in seed regions are involved in more pathways.

Overall, our results demonstrate that SNPs in clustered miRNA seed regions can take part in more intricate and complex gene-regulating networks with lower functional cost by functional complementarity.

Moreover, our results also broaden current knowledge on the genetic variation in human miRNA seed regions.

American Psychological Association (APA)

He, Sha& Ou, Haiyan& Zhao, Cunyou& Zhang, Jian. 2018. Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1172697

Modern Language Association (MLA)

He, Sha…[et al.]. Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions. International Journal of Genomics No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1172697

American Medical Association (AMA)

He, Sha& Ou, Haiyan& Zhao, Cunyou& Zhang, Jian. Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1172697

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1172697