Comparing the Efficacy and Safety of Induction Therapies for the Treatment of Patients with Proliferative Lupus Nephritis in South Africa
المؤلفون المشاركون
Sogayise, Phelisa
Ekrikpo, Udeme
Gcelu, Ayanda
Davidson, Bianca
Wearne, Nicola
Okpechi-Samuel, Ugochi
Umeizudike, Theophilus Ifeanyichukwu
Chukwuonye, Innocent Ijezie
Okpechi, Ikechi
المصدر
International Journal of Nephrology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Lupus nephritis (LN) can be complicated with requirement for kidney replacement therapy and death.
Efficacy of induction therapies using mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVCYC) has been reported from studies, but there is limited data in Africans comparing both treatments in patients with proliferative LN.
Methods.
This was a retrospective study of patients with biopsy-proven proliferative LN diagnosed and treated with either MMF or IVCYC in a single centre in Cape Town, South Africa, over a 5-year period.
The primary outcome was attaining complete remission after completion of induction therapy.
Results.
Of the 84 patients included, mean age was 29.6 ± 10.4 years and there was a female preponderance (88.1%).
At baseline, there were significant differences in estimated glomerular filtration rate (eGFR) and presence of glomerular crescents between both groups (p≤0.05).
After completion of induction therapy, there was no significant difference in remission status (76.0% versus 87.5%; p=0.33) or relapse status (8.1% versus 10.3%; p=0.22) for the IVCYC and MMF groups, respectively.
Mortality rate for the IVCYC group was 5.5 per 10,000 person-days of follow-up compared to 1.5 per 10,000 person-days of follow-up for the MMF group (p=0.11), and there was no significant difference in infection-related adverse events between both groups.
Estimated GFR at baseline was the only predictor of death (OR: 1.0 [0.9–1.0]; p=0.001).
Conclusion.
This study shows similar outcomes following induction treatment with MMF or IVCYC in patients with biopsy-proven proliferative LN in South Africa.
However, a prospective and randomized study is needed to adequately assess these outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sogayise, Phelisa& Ekrikpo, Udeme& Gcelu, Ayanda& Davidson, Bianca& Wearne, Nicola& Okpechi-Samuel, Ugochi…[et al.]. 2020. Comparing the Efficacy and Safety of Induction Therapies for the Treatment of Patients with Proliferative Lupus Nephritis in South Africa. International Journal of Nephrology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1172743
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sogayise, Phelisa…[et al.]. Comparing the Efficacy and Safety of Induction Therapies for the Treatment of Patients with Proliferative Lupus Nephritis in South Africa. International Journal of Nephrology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1172743
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sogayise, Phelisa& Ekrikpo, Udeme& Gcelu, Ayanda& Davidson, Bianca& Wearne, Nicola& Okpechi-Samuel, Ugochi…[et al.]. Comparing the Efficacy and Safety of Induction Therapies for the Treatment of Patients with Proliferative Lupus Nephritis in South Africa. International Journal of Nephrology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1172743
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172743
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر