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ENA-78 Is a Novel Predictor of Wound Healing in Patients with Diabetic Foot Ulcers
المؤلفون المشاركون
Li, Juyi
Wang, Zhongjing
Deng, Aiping
Li, Yu-ming
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives.
Chronic foot ulceration is a severe complication of diabetes, driving morbidity and mortality.
The aim of our study was to identify novel biomarkers of impaired wound healing in diabetic foot ulcers.
Methods.
109 patients with neuropathic diabetic foot ulcers and 30 burn victims otherwise healthy participated.
Antibody-coated glass slide arrays were used to determine the levels of 80 human cytokines in pooled plasma or pooled wound exudate of diabetic foot ulcers with rapidly healing (RH, n=12) and matched nonhealing (NH, n=12) patients.
Potential biomarkers were confirmed in an independent cohort by enzyme-linked immunosorbent assay (ELISA).
Results.
Protein array profiling identified 27 proteins or 15 proteins significantly altered in protein profiling of pooled plasma or pooled wound exudate of 12 RH patients compared with 12 matched NH patients, respectively.
In an independent cohort, quantitative ELISA validation confirmed a decrease in MCP-2 and ENA-78 levels in NH patients versus RH patients or burn victims.
After adjusting for the traditional risk factors (sex, age, body mass index, fasting plasma glucose, ulcer area, HbA1C, diabetes duration, hyperlipidemia, and antibiotic therapy), only wound exudate level of ENA-78 remained having a significant association with an increased odds ratio (OR) for wound healing by binary logistic regression analysis (P<0.05).
Conclusion.
Decreased wound exudate ENA-78 was independently associated with wound healing of patients with diabetic foot.
Exudate ENA-78 level is implicated as a novel predictor of wound healing in patients with diabetic foot ulcers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Juyi& Wang, Zhongjing& Deng, Aiping& Li, Yu-ming. 2019. ENA-78 Is a Novel Predictor of Wound Healing in Patients with Diabetic Foot Ulcers. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1172847
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Juyi…[et al.]. ENA-78 Is a Novel Predictor of Wound Healing in Patients with Diabetic Foot Ulcers. Journal of Diabetes Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1172847
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Juyi& Wang, Zhongjing& Deng, Aiping& Li, Yu-ming. ENA-78 Is a Novel Predictor of Wound Healing in Patients with Diabetic Foot Ulcers. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1172847
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172847
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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