ENA-78 Is a Novel Predictor of Wound Healing in Patients with Diabetic Foot Ulcers
Joint Authors
Li, Juyi
Wang, Zhongjing
Deng, Aiping
Li, Yu-ming
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
Chronic foot ulceration is a severe complication of diabetes, driving morbidity and mortality.
The aim of our study was to identify novel biomarkers of impaired wound healing in diabetic foot ulcers.
Methods.
109 patients with neuropathic diabetic foot ulcers and 30 burn victims otherwise healthy participated.
Antibody-coated glass slide arrays were used to determine the levels of 80 human cytokines in pooled plasma or pooled wound exudate of diabetic foot ulcers with rapidly healing (RH, n=12) and matched nonhealing (NH, n=12) patients.
Potential biomarkers were confirmed in an independent cohort by enzyme-linked immunosorbent assay (ELISA).
Results.
Protein array profiling identified 27 proteins or 15 proteins significantly altered in protein profiling of pooled plasma or pooled wound exudate of 12 RH patients compared with 12 matched NH patients, respectively.
In an independent cohort, quantitative ELISA validation confirmed a decrease in MCP-2 and ENA-78 levels in NH patients versus RH patients or burn victims.
After adjusting for the traditional risk factors (sex, age, body mass index, fasting plasma glucose, ulcer area, HbA1C, diabetes duration, hyperlipidemia, and antibiotic therapy), only wound exudate level of ENA-78 remained having a significant association with an increased odds ratio (OR) for wound healing by binary logistic regression analysis (P<0.05).
Conclusion.
Decreased wound exudate ENA-78 was independently associated with wound healing of patients with diabetic foot.
Exudate ENA-78 level is implicated as a novel predictor of wound healing in patients with diabetic foot ulcers.
American Psychological Association (APA)
Li, Juyi& Wang, Zhongjing& Deng, Aiping& Li, Yu-ming. 2019. ENA-78 Is a Novel Predictor of Wound Healing in Patients with Diabetic Foot Ulcers. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1172847
Modern Language Association (MLA)
Li, Juyi…[et al.]. ENA-78 Is a Novel Predictor of Wound Healing in Patients with Diabetic Foot Ulcers. Journal of Diabetes Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1172847
American Medical Association (AMA)
Li, Juyi& Wang, Zhongjing& Deng, Aiping& Li, Yu-ming. ENA-78 Is a Novel Predictor of Wound Healing in Patients with Diabetic Foot Ulcers. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1172847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172847